Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice
文献类型：期刊论文
| 作者 | Niu, Haichen1; Zheng, Yingwei2; Huma, Tanzeel2,4; Rizak, Joshua D.2; Li, Ling3; Wang, Guimei3; Ren, He3; Xu, Liqi3; Yang, Jianzhen2; Ma, Yuanye2 |
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2013 |
| 卷号 | 103期号:3页码:526-534 |
| 关键词 | Olfaction Morphine Sensitization Conditioned place preference c-Fos ZnSO4 |
| 英文摘要 | Previous studies have shown that olfactory impairment by disrupting the olfactory epithelium prior to morphine administration attenuated the development addiction-related behaviors. However, it is unclear whether olfactory impairment will affect the expression of already established addiction-related behaviors. To address this issue, mice were conditioned with morphine to induce behavioral sensitization and condition placed preference (CPP). After an abstinence period, the animals were subjected to either an intranasal ZnSO4 effusion (ZnE) or sham treatment with saline. Behavioral sensitization and CPP reinstatement were evaluated 24 h later, as well as the expression of c-Fos protein, a marker of activated neural sites, in brain regions of interest. It was found that ZnE treatment attenuated morphine-induced behavioral sensitization and reinstatement of CPP. Compared to the saline-treated ones, the ZnE-treated animals showed reduced c-Fos expression in the nucleus accumbens (NAc) associated with behavioral sensitization, and in the NAc, cingulate cortex, dentate gyrus, amygdala, lateral hypothalamus and ventral tegmental area associated with CPP reinstatement. Together, these results demonstrated that acute olfactory impairment could attenuate already established addiction-related behaviors and expression of c-Fos in drug addiction related brain regions, perhaps by affecting the coordination between reward and motivational systems in the brain. (c) 2012 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 关键词[WOS] | SEEKING BEHAVIOR ; OPIOID RECEPTOR ; FOS EXPRESSION ; RATS ; RELAPSE ; COCAINE ; REWARD ; FOREBRAIN ; BULBECTOMY ; MECHANISM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314792100015 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1003]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 43007, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Lab Primate Neurosci, Kunming 650223, Peoples R China 3.Peoples Liberat Army, Kunming Gen Hosp Chengdu Mil Reg, Kunming 650032, Yunnan, Peoples R China 4.Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Lab Reprod Neuroendocrinol, Islamabad 45320, Pakistan |
| 推荐引用方式 GB/T 7714 | Niu, Haichen,Zheng, Yingwei,Huma, Tanzeel,et al. Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2013,103(3):526-534. |
| APA | Niu, Haichen.,Zheng, Yingwei.,Huma, Tanzeel.,Rizak, Joshua D..,Li, Ling.,...&Lei, Hao.(2013).Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,103(3),526-534. |
| MLA | Niu, Haichen,et al."Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 103.3(2013):526-534. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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