Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent
文献类型：期刊论文
| 作者 | Xiao, Yan1,2; Xue, Rong2; You, Tianyan1; Li, Xiaojing2; Pei, Fengkui2; Wang, Xuxia3; Lei, Hao3 |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2014-08-18 |
| 卷号 | 395页码:9-14 |
| 关键词 | MRI contrast agent Arabinogalactan Liver Relaxivity |
| 英文摘要 | A novel biocompatible macromolecule (AG-CM-EDA-DOTA-Gd) was synthesized as a liver magnetic resonance imaging (MRI) contrast agent. AG-CM-EDA-DOTA-Gd consisted of a carboxymethyl-arabinogalactan unit conjugated with gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd-DOTA) via ethylenediamine, and was specifically designed to bind to hepatocyte asialoglycoprotein in vivo, in an effort to develop a potential new tool for the diagnosis of liver diseases. The T-1-relaxivity (8.87 mmol(-1) L s(-1)) of AG-CM-EDA-DOTA-Gd was 1.86 times than that of Gd-DOTA (4.76 mmol(-1) L s(-1)) in D2O at 9.4 T and 25 degrees C. MRI experiments showed significant enhancement in rat liver following the intravenous administration of AG-CM-EDA-DOTA-Gd (0.094 mmol Gd3+/kg body weight), which persisted for longer than Gd-DOTA (0.098 mmol Gd3+/kg body weight). The mean percentage enhancements in the liver parenchyma were 85.2 +/- 6.5% and 19.3 +/- 3.3% for AG-CM-EDA-DOTA-Gd and Gd-DOTA, respectively. The results of this study therefore indicate that AG-CM-EDA-DOTA-Gd could be used as a potential liver-targeting contrast agent for MM. (C) 2014 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | GADOLINIUM CHELATE ; PROTON RELAXATION ; MRI ; COMPLEXES ; BINDING ; DESIGN ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000340985200002 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1430]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Natl Analyt Res Ctr Electrochem & Spect, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Yan,Xue, Rong,You, Tianyan,et al. Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent[J]. CARBOHYDRATE RESEARCH,2014,395:9-14. |
| APA | Xiao, Yan.,Xue, Rong.,You, Tianyan.,Li, Xiaojing.,Pei, Fengkui.,...&Lei, Hao.(2014).Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent.CARBOHYDRATE RESEARCH,395,9-14. |
| MLA | Xiao, Yan,et al."Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent".CARBOHYDRATE RESEARCH 395(2014):9-14. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。