Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy
文献类型：期刊论文
| 作者 | Zhang, Zeting1; Dai, Chenye1,2; Bai, Jia1,2; Xu, Guohua1; Liu, Maili1; Li, Conggang1 |
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
 |
| 出版日期 | 2014-03-01 |
| 卷号 | 1838期号:3页码:853-858 |
| 关键词 | alpha-Synuclein Protein membrane transient interaction Ca2+ function NMR spectroscopy |
| 英文摘要 | alpha-Synudein is involved in Parkinson's disease and its interaction with cell membrane is crucial to its pathological and physiological functions. Membrane properties, such as curvature and lipid composition, have been shown to affect the interactions by various techniques, but ion effects on alpha-synuclein membrane interactions remain elusive. Ca2+ dynamic fluctuation in neurons plays important roles in the onset of Parkinson's disease and its influx is considered as one of the reasons to cause cell death. Using solution Nuclear Magnetic Resonance (NMR) spectroscopy, here we show that Ca2+ can modulate alpha-synuclein membrane interactions through competitive binding to anionic lipids, resulting in dissociation of alpha-synuclein from membranes. These results suggest a negative modulatory effect of Ca2+ on membrane mediated normal function of alpha-synuclein, which may provide a clue, to their dysfunction in neurodegenerative disease. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ISLET AMYLOID POLYPEPTIDE ; PARKINSONS-DISEASE ; PHOSPHOLIPID-BINDING ; IN-VIVO ; PROTEIN ; AGGREGATION ; VESICLES ; MUTATION ; CALCIUM ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331661800014 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1432]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zeting,Dai, Chenye,Bai, Jia,et al. Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,2014,1838(3):853-858. |
| APA | Zhang, Zeting,Dai, Chenye,Bai, Jia,Xu, Guohua,Liu, Maili,&Li, Conggang.(2014).Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES,1838(3),853-858. |
| MLA | Zhang, Zeting,et al."Ca2+ modulating alpha-synuclein membrane transient interactions revealed by solution NMR spectroscopy".BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838.3(2014):853-858. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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