The Molecular Structure of Alzheimer beta-Amyloid Fibrils Formed in the Presence of Phospholipid Vesicles
文献类型：期刊论文
| 作者 | Niu, Zheng; Zhao, Weijing; Zhang, Zhengfeng; Xiao, Fanshu; Tang, Xinqi; Yang, Jun |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2014-08-25 |
| 卷号 | 53期号:35页码:9294-9297 |
| 关键词 | Alzheimer's disease beta-amyloid aggregation magic-angle spinning NMR spectroscopy protein structures |
| 英文摘要 | beta-amyloid (A beta) fibrils are the major species involved in Alzheimer's disease (AD). An atomic-resolution molecular structure of A beta 40 fibrils formed in the presence of lipid vesicles was obtained by using magic angle spinning (MAS) solid-state NMR spectroscopy. The fibril structures formed in the presence of the lipid vesicles are remarkably different from those formed in solution. These results provide insights into the molecular mechanism of A beta aggregation in the presence of lipid vesicles. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SOLID-STATE NMR ; SECONDARY STRUCTURE ; CHEMICAL-SHIFTS ; LIPID-MEMBRANES ; PEPTIDE ; POLYMORPHISM ; PROTEIN ; FIBRILLOGENESIS ; SPECTROSCOPY ; OLIGOMERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342676100031 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1456]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Zheng,Zhao, Weijing,Zhang, Zhengfeng,et al. The Molecular Structure of Alzheimer beta-Amyloid Fibrils Formed in the Presence of Phospholipid Vesicles[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(35):9294-9297. |
| APA | Niu, Zheng,Zhao, Weijing,Zhang, Zhengfeng,Xiao, Fanshu,Tang, Xinqi,&Yang, Jun.(2014).The Molecular Structure of Alzheimer beta-Amyloid Fibrils Formed in the Presence of Phospholipid Vesicles.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(35),9294-9297. |
| MLA | Niu, Zheng,et al."The Molecular Structure of Alzheimer beta-Amyloid Fibrils Formed in the Presence of Phospholipid Vesicles".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.35(2014):9294-9297. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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