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Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier
文献类型：期刊论文
| 作者 | Yan, Huihui4; Wang, Lu2,3; Wang, Jiyao4; Weng, Xiaofu5,6; Lei, Hao1; Wang, Xuxia1; Jiang, Lu7; Zhu, Jianhua2,3; Lu, Weiyue2,3; Wei, Xunbin5,6 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2012 |
| 卷号 | 6期号:1页码:410-420 |
| 关键词 | brain tumor nanoprobe multimodal imaging blood brain barrier two-order targeting |
| 英文摘要 | Surgical resection is a mainstay of brain tumor treatments. However, the completed excision of malignant brain tumor Is challenged by its infiltrative nature. Contrast enhanced magnetic resonance imaging is widely used for defining brain tumor in clinic. However its ability in tumor visualization is hindered by the transient circulation lifetime, nontargeting specificity, and poor blood brain barrier (BBB) permeability of the commercially available MR contrast agents. In this work, we developed a two-order targeted nanoprobe in which MR/optical imaging reporters, tumor vasculature targeted cydic (RGDyk] peptides, and BBB-permeable Angiopep-2 peptides are labeled on the PAMAM-G5 dendrimer. This nanoprobe is supposed to first target the alpha(v)beta(3) integrin on tumor vasculatures. Increased local concentration of nanoprobe facilitates the association between BBB-permeable peptides and the low-density lipoprotein receptor-related protein (LRP) receptors on the vascular endothelial cells, which further accelerates BBB transverse of the nanoprobe via LRP receptor-mediated endocytosis. The nanoprobes that have penetrated the BBB secondly target the brain tumor because both alpha(v)beta(3) integrin and LRP receptor are highly expressed on the tumor cells. In vivo Imaging studies demonstrated that this nanoprobe not only efficiently crossed intact BBB In normal mice, but also precisely delineated the boundary of the orthotropic U87MG human glioblastoma xenograft with high target to background signal ratio. Overall, this two-order targeted nanoprobe holds the promise to noninvasively visualize brain tumors with uncompromised BBB and provides the possibility for real-time optical-image-guided brain tumor resection during surgery. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | DRUG-DELIVERY ; MALIGNANT GLIOMA ; IN-VIVO ; GENE DELIVERY ; TROJAN HORSES ; CANCER ; RECEPTOR ; NANOPARTICLES ; CLEARANCE ; PEPTIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299368300051 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1594]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Shanghai 201203, Peoples R China 3.Fudan Univ, PLA, Sch Pharm, Shanghai 201203, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China 5.Shanghai Jiao Tong Univ, Med Res Inst X, Shanghai 200030, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China 7.Johns Hopkins Univ, Sch Med, JHU ICMIC Program, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21205 USA |
| 推荐引用方式 GB/T 7714 | Yan, Huihui,Wang, Lu,Wang, Jiyao,et al. Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier[J]. ACS NANO,2012,6(1):410-420. |
| APA | Yan, Huihui.,Wang, Lu.,Wang, Jiyao.,Weng, Xiaofu.,Lei, Hao.,...&Li, Cong.(2012).Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier.ACS NANO,6(1),410-420. |
| MLA | Yan, Huihui,et al."Two-Order Targeted Brain Tumor Imaging by Using an Optical/Paramagnetic Nanoprobe across the Blood Brain Barrier".ACS NANO 6.1(2012):410-420. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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