热门
Ultrasmall Water-Soluble and Biocompatible Magnetic Iron Oxide Nanoparticles as Positive and Negative Dual Contrast Agents
文献类型：期刊论文
| 作者 | Li, Zhen1; Yi, Pei Wei2; Sun, Qiao3; Lei, Hao2; Zhao, Hong Li4; Zhu, Zhong Hua5; Smith, Sean C.3; Lan, Min Bo4; Lu, Gao Qing (Max)1 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2012-06-06 |
| 卷号 | 22期号:11页码:2387-2393 |
| 关键词 | dual contrast agents iron oxide magnetic resonance imaging magnetic nanoparticles coprecipitation |
| 英文摘要 | Monodispersed water-soluble and biocompatible ultrasmall magnetic iron oxide nanoparticles (UMIONs, D = 3.3 +/- 0.5 nm) generated from a high-temperature coprecipitation route are successfully used as efficient positive and negative dual contrast agents of magnetic resonance imaging (MRI). Their longitudinal relaxivity at 4.7 T (r1 = 8.3 mM-1 s-1) is larger than that of clinically used T1-positive agent Gd-DTPA (r1 = 4.8 mM-1 s-1), and three times that of commercial contrast agent SHU-555C (r1 = 2.9 mM-1 s-1). The transversal relaxivity (r2 = 35.1 mM-1 s-1) is six times that of Gd-DTPA (r2 = 5.3 mM-1 s-1), half of SHU-555C (r2 = 69 mM-1 s-1). The in vivo results show that the liver signal from T1-weighted MRI is positively enhanced 26%, and then negatively decreased 20% after injection of the iron oxide nanoparticles, which is stronger than those obtained from Gd-DTPA (<10%) using the same dosage. The kidney signal is positively enhanced up to 35%, similar to that obtained from Gd-DTPA. Under T2-weighted conditions, the liver signal is negatively enhanced ?70%, which is significantly higher than that from Gd-DTPA (?6%). These results demonstrate the great potential of the UMIONs in dual contrast agents, especially as an alternative to Gd-based positive contrast agents, which have risks of inducing side effects in patients. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 关键词[WOS] | SIZE-CONTROLLED SYNTHESIS ; MONODISPERSE GOLD NANOPARTICLES ; ONE-POT REACTION ; POLYMERIC STABILIZERS ; NANOCRYSTALS ; MRI ; DESIGN ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000304749600019 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1726]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Univ Queensland, ARC Ctr Excellence Funct Nanomat, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, WuHan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Univ Queensland, Ctr Computat Mol Sci, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia 4.E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China 5.Univ Queensland, Sch Chem Engn, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Li, Zhen,Yi, Pei Wei,Sun, Qiao,et al. Ultrasmall Water-Soluble and Biocompatible Magnetic Iron Oxide Nanoparticles as Positive and Negative Dual Contrast Agents[J]. ADVANCED FUNCTIONAL MATERIALS,2012,22(11):2387-2393. |
| APA | Li, Zhen.,Yi, Pei Wei.,Sun, Qiao.,Lei, Hao.,Zhao, Hong Li.,...&Lu, Gao Qing .(2012).Ultrasmall Water-Soluble and Biocompatible Magnetic Iron Oxide Nanoparticles as Positive and Negative Dual Contrast Agents.ADVANCED FUNCTIONAL MATERIALS,22(11),2387-2393. |
| MLA | Li, Zhen,et al."Ultrasmall Water-Soluble and Biocompatible Magnetic Iron Oxide Nanoparticles as Positive and Negative Dual Contrast Agents".ADVANCED FUNCTIONAL MATERIALS 22.11(2012):2387-2393. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。