Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice
文献类型：期刊论文
| 作者 | Liu, Qing1,3; Li, Anan1; Gong, Ling1,3; Zhang, Lei3,4; Wu, Nan1; Xu, Fuqiang1,2 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2013-06-17 |
| 卷号 | 545页码:81-85 |
| 关键词 | Alzheimer's disease Olfactory bulb Coherence Beta oscillation Awake animals |
| 英文摘要 | Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by cell and synapse losses and the ensued network disconnections. Olfactory impairment is common and occurs early in AD patients, suggesting its potential role in the early diagnosis of AD. However, the functional connectivity of the olfactory system in AD has received little attention. Using local field potentials symmetrically recorded from the two olfactory bulbs in awake mice, we found that in AD model mice with robust amyloid-beta burden, the coherence between the two bulbs for spontaneous activities was significantly lower in all of the four frequency bands (theta, beta, low and high gamma: 2-12, 15-35, 35-65 and 65-100 Hz, respectively). Moreover, the coherence for odor-evoked activities was also lower, particularly in the beta band, when compared to their wild-type littermates. These results demonstrate that the inter-bulbar functional connectivity is impaired in AD mice, indicating a failure of brain activation in beta-related functions, which might be of importance in the diagnosis of AD. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | RESTING-STATE FMRI ; EEG COHERENCE ; FUNCTIONAL CONNECTIVITY ; BEHAVIORAL IMPAIRMENTS ; PHOTIC-STIMULATION ; BETA-OSCILLATIONS ; NETWORK ACTIVITY ; MOUSE MODEL ; SYSTEM ; CORTEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321031600016 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/793]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Kunming 650223, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qing,Li, Anan,Gong, Ling,et al. Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice[J]. NEUROSCIENCE LETTERS,2013,545:81-85. |
| APA | Liu, Qing,Li, Anan,Gong, Ling,Zhang, Lei,Wu, Nan,&Xu, Fuqiang.(2013).Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice.NEUROSCIENCE LETTERS,545,81-85. |
| MLA | Liu, Qing,et al."Decreased coherence between the two olfactory bulbs in Alzheimer's disease model mice".NEUROSCIENCE LETTERS 545(2013):81-85. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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