Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking
文献类型：期刊论文
| 作者 | Solecki, Wojciech1; Wickham, Robert J.1,2; Behrens, Shay1; Wang, Jie3,4; Zwerling, Blake1; Mason, Graeme F.1,3; Addy, Nii A.1,2,5 |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2013-12-01 |
| 卷号 | 75页码:9-18 |
| 关键词 | Drug-seeking NMDA Acetylcholine Phasic dopamine Ventral tegmental area Nucleus accumbens |
| 英文摘要 | Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Cues evoke burst firing of ventral tegmental area (VTA) dopamine (DA) neurons and phasic DA release in the nucleus accumbens (NAc). Cholinergic and glutamatergic input to the VTA is suggested to gate phasic DA activity. However, the role of VTA cholinergic and glutamatergic receptors in regulating phasic dopamine release and cue-induced drug-seeking in cocaine experienced subjects is not known. In male Sprague-Dawley rats, we found that VTA inactivation strongly inhibited, while VTA stimulation promoted, cocaine-seeking behavior during early withdrawal. Blockade of phasic activated D1 receptors in the NAc core also strongly inhibited cue-induced cocaine-seeking - suggesting an important role of phasic DA activity in the VTA to NAc core circuit. Next, we examined the role of VTA acetylcholine receptors (AChRs) and N-methyl-D-aspartate receptors (NMDARs) in regulating both NAc core phasic DA release and cue-induced cocaine-seeking. In cocaine naive subjects, VTA infusion of the nicotinic acetylcholine receptor (AChR) antagonist mecamylamine, the muscarinic AChR antagonist scopolamine, or the NMDAR antagonist AP-5, led to robust attenuation of phasic DA release in the NAc core. During early cocaine withdrawal, VTA infusion of AP-5 had limited effects on NAc phasic DA release and cue-induced cocaine-seeking while VTA infusion of mecamylamine or scopolamine robustly inhibited both phasic DA release and cocaine-seeking. The results demonstrate that VTA AChRs, but not NMDARs, strongly regulate cue-induced cocaine-seeking and phasic DA release during early cocaine withdrawal. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 关键词[WOS] | EXTRACELLULAR DOPAMINE LEVELS ; REWARD-PREDICTIVE CUES ; NUCLEUS-ACCUMBENS ; INDUCED REINSTATEMENT ; DRUG-SEEKING ; BEHAVIOR ; NEURONS ; RELEASE ; RATS ; GLUTAMATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330490300002 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/827]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA 2.Yale Univ, Interdept Neurosci Program, New Haven, CT 06520 USA 3.Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA 4.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan, Hubei, Peoples R China 5.Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA |
| 推荐引用方式 GB/T 7714 | Solecki, Wojciech,Wickham, Robert J.,Behrens, Shay,et al. Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking[J]. NEUROPHARMACOLOGY,2013,75:9-18. |
| APA | Solecki, Wojciech.,Wickham, Robert J..,Behrens, Shay.,Wang, Jie.,Zwerling, Blake.,...&Addy, Nii A..(2013).Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking.NEUROPHARMACOLOGY,75,9-18. |
| MLA | Solecki, Wojciech,et al."Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking".NEUROPHARMACOLOGY 75(2013):9-18. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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