Nano-cellulose 3D-networks as controlled-release drug carriers
文献类型：期刊论文
| 作者 | Huang, Lin1,2; Chen, Xiuli1,2; Thanh Xuan Nguyen1,2; Tang, Huiru3; Zhang, Liming3; Yang, Guang1,2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2013 |
| 卷号 | 1期号:23页码:2976-2984 |
| 英文摘要 | Bacterial cellulose (BC) membranes are used as the carrier for berberine hydrochloride and berberine sulphate to produce a new controlled release system. Release studies and transdermal experiments were carried out in vitro. Carrier BC can significantly extend the drug release time, in contrast to existing commercial carriers. Freeze-dried BC membranes 10 mm thick were optimized for drug delivery. The lowest release rate was in simulated gastric fluid (SGF) or in H2SO4 solution, the highest in simulated intestinal fluid (SIF) and an intermediate rate was found in alkaline conditions. The release curves closely followed the Ritger-Peppas model with free diffusion the most prominent mechanism. Scanning electron microscopy (SEM) analysis demonstrated that BC fibers were swollen in acid and base conditions. H-1 high-resolution magic angle spinning nuclear magnetic resonance (H-1 HRMAS NMR) diffusion-ordered spectroscopy (DOSY) analysis showed that there was an interaction between the drugs and BC. The structure of BC, the media and the solubility of the drug all influenced the sustained-release behavior. The results from the release studies, the electron micrographs, and the transdermal experiments were in good agreement. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Materials Science, Biomaterials |
| 研究领域[WOS] | Materials Science |
| 关键词[WOS] | CONGESTIVE-HEART-FAILURE ; BACTERIAL CELLULOSE ; MICROBIAL CELLULOSE ; BERBERINE ; DIFFUSION ; ASSOCIATION ; COMPOSITES ; METABOLISM ; INHIBITION ; NANOFIBERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000319273100011 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/849]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Biomed Engn, Wuhan 430074, Peoples R China 2.Huazhong Univ Sci & Technol, Natl Engn Res Ctr Nanomed, Wuhan 430074, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Lin,Chen, Xiuli,Thanh Xuan Nguyen,et al. Nano-cellulose 3D-networks as controlled-release drug carriers[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(23):2976-2984. |
| APA | Huang, Lin,Chen, Xiuli,Thanh Xuan Nguyen,Tang, Huiru,Zhang, Liming,&Yang, Guang.(2013).Nano-cellulose 3D-networks as controlled-release drug carriers.JOURNAL OF MATERIALS CHEMISTRY B,1(23),2976-2984. |
| MLA | Huang, Lin,et al."Nano-cellulose 3D-networks as controlled-release drug carriers".JOURNAL OF MATERIALS CHEMISTRY B 1.23(2013):2976-2984. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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