Multiple Univariate Data Analysis Reveals the Inulin Effects on the High-Fat-Diet Induced Metabolic Alterations in Rat Myocardium and Testicles in the Preobesity State
文献类型：期刊论文
| 作者 | Duan, Yixuan1,2; An, Yanpeng2,3; Li, Ning2,3; Liu, Bifeng1; Wang, Yulan2; Tang, Huiru2 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2013-07-01 |
| 卷号 | 12期号:7页码:3480-3495 |
| 关键词 | high-fat diet inulin metabonomics MUDA myocardium reproductive system |
| 英文摘要 | Obesity is a worldwide epidemic and a well known risk factor for many diseases affecting billions of people's health and well-being. However, little information is available for metabolic changes associated with the effects of obesity development and interventions on cardiovascular and reproduction systems. Here, we systematically analyzed the effects of high-fat diet (HFD) and inulin intake on the metabolite compositions of myocardium and testicle using NMR spectroscopy. We developed a useful high throughput method based on multiple univariate data analysis (MUDA) to visualize and efficiently extract information on metabolites significantly affected by an intervention. We found that HFD caused widespread metabolic changes in both rat myocardium and testicles involving fatty acid beta-oxidation together with the metabolisms of choline, amino acids, purines and pyrimidines even before HFD caused significant body-weight increases. Inulin intake ameliorated some of the HFD-induced metabolic changes in both myocardium (3-HB, lactate and guanosine) and testicle tissues (3-HB, inosine and betaine). A remarkable elevation of scyllo-inositol was also observable with inulin intake in both tissues. These findings offered essential information for the inulin effects on the HFD-induced metabolic changes and demonstrated this MUDA method as a powerful alternative to traditionally used multivariate data analysis for metabonomics. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | MULTIVARIATE DATA-ANALYSIS ; H-1-NMR SPECTROSCOPY ; ADIPOSE-TISSUE ; LOW-CARBOHYDRATE ; SYSTEMS BIOLOGY ; INDUCED OBESITY ; GUT MICROBIOTA ; LIVER-DISEASE ; HUMAN URINE ; WEIGHT-LOSS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321605700038 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/853]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Hubei Bioinformat & Mol Imaging Key Lab, Britton Chance Ctr Biomed Photon,Dept Biomed Engn, Wuhan Natl Lab Optoelect,Coll Life Sci & Technol, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Ctr Biospect & Metabon,Wuhan Inst Phys & Math, Wuhan 430079, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Yixuan,An, Yanpeng,Li, Ning,et al. Multiple Univariate Data Analysis Reveals the Inulin Effects on the High-Fat-Diet Induced Metabolic Alterations in Rat Myocardium and Testicles in the Preobesity State[J]. JOURNAL OF PROTEOME RESEARCH,2013,12(7):3480-3495. |
| APA | Duan, Yixuan,An, Yanpeng,Li, Ning,Liu, Bifeng,Wang, Yulan,&Tang, Huiru.(2013).Multiple Univariate Data Analysis Reveals the Inulin Effects on the High-Fat-Diet Induced Metabolic Alterations in Rat Myocardium and Testicles in the Preobesity State.JOURNAL OF PROTEOME RESEARCH,12(7),3480-3495. |
| MLA | Duan, Yixuan,et al."Multiple Univariate Data Analysis Reveals the Inulin Effects on the High-Fat-Diet Induced Metabolic Alterations in Rat Myocardium and Testicles in the Preobesity State".JOURNAL OF PROTEOME RESEARCH 12.7(2013):3480-3495. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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