Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus)
文献类型：期刊论文
| 作者 | Li, Li1; Xie, Ping2; Lei, Hehua3; Zhang, Xuezhen1 |
| 刊名 | TOXICON
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 70页码:62-69 |
| 关键词 | Microcystins Nephrotoxic Intraperitoneal injection Crucian carp Ultrastructural changes |
| 英文摘要 | An acute toxicological experiment was designed to characterize the sequence of renal ultrastructural changes with accumulated MCs in crucian carp injected intraperitoneally (i.p.) with extracted microcystins (mainly MC-RR and -LR) at two doses, 50 and 200 mu g MC-LReq. kg(-1) body weight. Quantitative and qualitative determinations of MCs in the kidney were conducted by HPLC and LC-MS, respectively. MC-RR content in kidney of crucian carp showed a time dose-dependent increase within 48 h post-injection, followed by a sharp decline afterward, while no MC-LR in kidney was detectable throughout the experiment. Ultrastructural changes in the kidney of crucian carp progressed with increasing accumulated MCs and exposure times within 48 h post-injection, whereas renal ultrastructural recovery of crucian carp in the 50 mu g MC-LReq. kg(-1) dose group was evident at 168 h post-injection. Our ultrastructural observation suggests that the membranous structure is the main action site of MCs in the kidney, among which mitochondria damage in the tubules is clearly an early, and presumably a critically important effect of MCs. The increases in blood urea nitrogen (BUN) and creatinine (CR) in both dose groups further revealed severe impairment occurred in the kidney of crucian carp. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | PHYTOPLANKTIVOROUS SILVER CARP ; TOXIC CYANOBACTERIAL BLOOMS ; DIFFERENT TROPHIC LEVELS ; FISH OREOCHROMIS SP. ; LABORATORY CONDITIONS ; BIGHEAD CARP ; IN-SITU ; BIOCHEMICAL-CHARACTERIZATION ; TISSUE DISTRIBUTION ; OXIDATIVE STRESS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000321537200008 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/904]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Minist Agr, Key Lab Freshwater Anim Breeding, Wuhan 430070, Peoples R China 2.Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Li,Xie, Ping,Lei, Hehua,et al. Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus)[J]. TOXICON,2013,70:62-69. |
| APA | Li, Li,Xie, Ping,Lei, Hehua,&Zhang, Xuezhen.(2013).Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus).TOXICON,70,62-69. |
| MLA | Li, Li,et al."Renal accumulation and effects of intraperitoneal injection of extracted microcystins in omnivorous crucian carp (Carassius auratus)".TOXICON 70(2013):62-69. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。