Gallic Acid Intake Induces Alterations to Systems Metabolism in Rats
文献类型：期刊论文
| 作者 | Shi, Xiaohuo1,3; Xiao, Chaoni2; Wang, Yulan1; Tang, Huiru1 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2013-02-01 |
| 卷号 | 12期号:2页码:991-1006 |
| 关键词 | gallic acid polyphenols NMR metabonomics stress response nutrimetabonomics |
| 英文摘要 | Gallic acid (GA) and its metabolites are polyphenolic compounds present in daily diets and herbal medicines. To understand the GA effects on the endogenous metabolism of mammals, we systematically analyzed the metabonomic responses of rat plasma, liver, urine, and feces to a single GA dosage of 120 and 600 mg/kg, which were below the no-obvious-adverse-effect-level of 1 g/kg for rats. Clinical chemistry and histopathological assessments were conducted to provide complementary information. Our results showed that GA intake induced significant metabonomic changes in multiple rat biological matrices. Such changes were more outstanding in liver than in the other matrices and dearly showed dose- and time-dependence. The results suggested GA-induced promotion of oxidative stress as the major effect. High-dose GA caused significant metabolic changes involving glycogenolysis, glycolysis, TCA cycle, and metabolism of amino acids, purines, and pyrimidines, together with gut microbiota functions. Low-dose GA only caused some urinary metabonomic changes and to a much less degree. The GA-induced liver metabonomic changes were not completely recoverable within a week, although such recovery completed in plasma, urine, and feces within 80 h. These findings provided new essential information on the effects of dietary polyphenols and demonstrated the great potential of this nutrimetabonomics approach. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | METABONOMIC TECHNIQUES ; H-1-NMR SPECTROSCOPY ; DIETARY ISOFLAVONES ; PHENOLIC SUBSTANCES ; XANTHINE-OXIDASE ; POLYPHENOLS ; HUMANS ; H-1 ; DERIVATIVES ; FLAVONOIDS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000314558800040 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/910]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst,Wuhan Inst Phy, State Key Lab Magnet Resonance & Atom & Mol Phys, Ctr Biospect & Metabon,Wuhan Ctr Magnet Resonance, Wuhan 430071, Peoples R China 2.NW Univ Xian, Coll Life Sci, Xian 710069, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Xiaohuo,Xiao, Chaoni,Wang, Yulan,et al. Gallic Acid Intake Induces Alterations to Systems Metabolism in Rats[J]. JOURNAL OF PROTEOME RESEARCH,2013,12(2):991-1006. |
| APA | Shi, Xiaohuo,Xiao, Chaoni,Wang, Yulan,&Tang, Huiru.(2013).Gallic Acid Intake Induces Alterations to Systems Metabolism in Rats.JOURNAL OF PROTEOME RESEARCH,12(2),991-1006. |
| MLA | Shi, Xiaohuo,et al."Gallic Acid Intake Induces Alterations to Systems Metabolism in Rats".JOURNAL OF PROTEOME RESEARCH 12.2(2013):991-1006. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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