Synthesis and biological response of casein-based silica nano-composite film for drug delivery system
文献类型：期刊论文
| 作者 | Ma, Jianzhong1; Xu, Qunna1; Zhou, Jianhua1; Zhang, Jing2; Zhang, Limin3; Tang, Huiru3; Chen, Lihong1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2013-11-01 |
| 卷号 | 111页码:257-263 |
| 关键词 | Composite Drug delivery In vitro test Microsphere Biocompatibility Microstructure |
| 英文摘要 | Casein possesses many interesting properties that make it a good candidate for conventional and novel drug delivery systems. In this study, casein-based silica nano-composite was prepared via double in situ method, and the as-prepared latex particles were evaluated in terms of their morphology and size through transmission electron microscopy (TEM). The film morphology was investigated by scanning electron microscopy (SEM) and energy dispersive X-ray (EDX), and the mechanical property and response behavior of the films as a function of silica content were discussed. Ibuprofen was used as the model drug. The drug load and release properties were studied by solid-state nuclear magnetic resonance (solid-state NMR), Fourier transform infrared (FT-IR), SEM and in vitro test. The composite latex particle showed a stable core shell structure, and the film exhibited a regular surface with even SiO2 distribution. The drug load efficiency of the composite films increased with adding silica because of the adsorption of the drugs on the silica. In an acidic release medium, the ibuprofen-loaded composite showed a slower drug release dependent on the silica content. These behaviors were most likely due to the reduced diffusion rate of the drug through the composite microsphere, which resulted from the interaction between the silica and the drug. (C) 2013 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences ; Technology |
| 类目[WOS] | Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Biophysics ; Chemistry ; Materials Science |
| 关键词[WOS] | LEATHER FINISHING AGENT ; EMULSION POLYMERIZATION ; MECHANICAL-PROPERTIES ; CONTROLLED-RELEASE ; HYBRID ; MICROPARTICLES ; PARTICLES ; HYDROGELS ; PROTEINS ; DEVICES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000324897900032 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/950]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Shaanxi Univ Sci & Technol, Coll Resources & Environm, Xian 710021, Shaanxi Provinc, Peoples R China 2.Shaanxi Univ Sci & Technol, Coll Foreign Languages & Commun, Xian 710021, Shaanxi Provinc, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Magnet Resonance Ctr, Spectrum & State Key Lab Atom & Mol, Wuhan 430071, Hubei Province, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Jianzhong,Xu, Qunna,Zhou, Jianhua,et al. Synthesis and biological response of casein-based silica nano-composite film for drug delivery system[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2013,111:257-263. |
| APA | Ma, Jianzhong.,Xu, Qunna.,Zhou, Jianhua.,Zhang, Jing.,Zhang, Limin.,...&Chen, Lihong.(2013).Synthesis and biological response of casein-based silica nano-composite film for drug delivery system.COLLOIDS AND SURFACES B-BIOINTERFACES,111,257-263. |
| MLA | Ma, Jianzhong,et al."Synthesis and biological response of casein-based silica nano-composite film for drug delivery system".COLLOIDS AND SURFACES B-BIOINTERFACES 111(2013):257-263. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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