Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones
文献类型：期刊论文
| 作者 | Xu, Zhixiang1,3; Gao, Yunling1,3; Xu, Fuqiang1,2 |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2013-04-29 |
| 卷号 | 541页码:269-274 |
| 关键词 | Olfactory deficits ZnSO4 irrigation BrdU incorporation Cell proliferation Subventricular zone Subgranular zone |
| 英文摘要 | Constitutive adult neurogenesis mainly occurs in the subgranular zone (SGZ) and subventricular zone (SVZ) of the mammalian brain. Intrinsic and extrinsic factors regulate adult neurogenesis processes including cell proliferation, migration, integration and neural survival. The potential contribution of olfactory sensory input to the regulation of adult neurogenesis, especially neurogenesis in the dentate gyrus, however, is not well studied. In the present study, we examined the effects of deficits in the peripheral olfactory inputs on cell proliferation in the adult SGZ and SVZ. With an anosmic model produced by ZnSO4 irrigation of the olfactory epithelium, we found that in the adult SVZ and SGZ the numbers of both BrdU labeled cells and doublecortin labeled cells (immature neurons) were significantly decreased, whereas the number of adult stem cells was not significantly altered. These results suggested that olfactory sensory input may play roles in regulating adult neurogenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | NEURAL STEM-CELLS ; NEURODEGENERATIVE DISEASE ; HIPPOCAMPAL NEUROGENESIS ; MOUSE ; BULB ; SYSTEM ; RATS ; DEPRESSION ; SURVIVAL ; SEIZURES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000318531400053 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/959]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Zhixiang,Gao, Yunling,Xu, Fuqiang. Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones[J]. NEUROSCIENCE LETTERS,2013,541:269-274. |
| APA | Xu, Zhixiang,Gao, Yunling,&Xu, Fuqiang.(2013).Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones.NEUROSCIENCE LETTERS,541,269-274. |
| MLA | Xu, Zhixiang,et al."Deficits of peripheral olfactory inputs reduce cell proliferation in the adult subventricular and subgranular zones".NEUROSCIENCE LETTERS 541(2013):269-274. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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