Numerical Simulation of Airway Dimension Effects on Airflow Patterns and Odorant Deposition Patterns in the Rat Nasal Cavity
文献类型：期刊论文
| 作者 | Wei, Zehong1,2; Xu, Zhixiang2; Li, Bo2; Xu, Fuqiang1,2 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2013-10-28 |
| 卷号 | 8期号:10 |
| 英文摘要 | The sense of smell is largely dependent on the airflow and odorant transport in the nasal cavity, which in turn depends on the anatomical structure of the nose. In order to evaluate the effect of airway dimension on rat nasal airflow patterns and odorant deposition patterns, we constructed two 3-dimensional, anatomically accurate models of the left nasal cavity of a Sprague-Dawley rat: one was based on high-resolution MRI images with relatively narrow airways and the other was based on artificially-widening airways of the MRI images by referencing the section images with relatively wide airways. Airflow and odorant transport, in the two models, were determined using the method of computational fluid dynamics with finite volume method. The results demonstrated that an increase of 34 mm in nasal airway dimension significantly decreased the average velocity in the whole nasal cavity by about 10% and in the olfactory region by about 12% and increased the volumetric flow into the olfactory region by about 3%. Odorant deposition was affected to a larger extent, especially in the olfactory region, where the maximum odorant deposition difference reached one order of magnitude. The results suggest that a more accurate nasal cavity model is necessary in order to more precisely study the olfactory function of the nose when using the rat. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | COMPUTATIONAL FLUID-DYNAMICS ; COMPUTER-SIMULATION ; INHALED FORMALDEHYDE ; ACOUSTIC RHINOMETRY ; OLFACTORY MUCOSA ; FUNCTIONAL MRI ; RHESUS-MONKEY ; SINUS SURGERY ; HUMAN NOSE ; F344 RAT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326241200033 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/985]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Wuhan Natl Lab Optoelect, Div Biomed Photon, Wuhan, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance Atom & Mol Phys, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Zehong,Xu, Zhixiang,Li, Bo,et al. Numerical Simulation of Airway Dimension Effects on Airflow Patterns and Odorant Deposition Patterns in the Rat Nasal Cavity[J]. PLOS ONE,2013,8(10). |
| APA | Wei, Zehong,Xu, Zhixiang,Li, Bo,&Xu, Fuqiang.(2013).Numerical Simulation of Airway Dimension Effects on Airflow Patterns and Odorant Deposition Patterns in the Rat Nasal Cavity.PLOS ONE,8(10). |
| MLA | Wei, Zehong,et al."Numerical Simulation of Airway Dimension Effects on Airflow Patterns and Odorant Deposition Patterns in the Rat Nasal Cavity".PLOS ONE 8.10(2013). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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