Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure
文献类型：期刊论文
| 作者 | Wang, Jie1,2; Du, Hongying2,4; Jiang, Lihong2; Ma, Xiaoxian2; de Graaf, Robin A.2; Behar, Kevin L.3; Mason, Graeme F.2,3 |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2013-08-27 |
| 卷号 | 110期号:35页码:14444-14449 |
| 关键词 | 13C-NMR catalase alcohol dehydrogenase cytochrome P450 acetaldehyde dehydrogenase |
| 英文摘要 | It has been reported that chronic and acute alcohol exposure decreases cerebral glucose metabolism and increases acetate oxidation. However, it remains unknown how much ethanol the living brain can oxidize directly and whether such a process would be affected by alcohol exposure. The questions have implications for reward, oxidative damage, and long-term adaptation to drinking. One group of adult male Sprague-Dawley rats was treated with ethanol vapor and the other given room air. After 3 wk the rats received i.v. [2-C-13]ethanol and [1, 2-C-13(2)]acetate for 2 h, and then the brain was fixed, removed, and divided into neocortex and subcortical tissues for measurement of C-13 isotopic labeling of glutamate and glutamine by magnetic resonance spectroscopy. Ethanol oxidation was seen to occur both in the cortex and the subcortex. In ethanol-naive rats, cortical oxidation of ethanol occurred at rates of 0.017 +/- 0.002 mu mol/min/g in astroglia and 0.014 +/- 0.003 mu mol/min/g in neurons, and chronic alcohol exposure increased the astroglial ethanol oxidation to 0.028 +/- 0.002 mu mol/min/g (P = 0.001) with an insignificant effect on neuronal ethanol oxidation. Compared with published rates of overall oxidative metabolism in astroglia and neurons, ethanol provided 12.3 +/- 1.4% of cortical astroglial oxidation in ethanol-naive rats and 20.2 +/- 1.5% in ethanol-treated rats. For cortical astroglia and neurons combined, the ethanol oxidation for naive and treated rats was 3.2 +/- 0.3% and 3.8 +/- 0.2% of total oxidation, respectively. C-13 labeling from subcortical oxidation of ethanol was similar to that seen in cortex but was not affected by chronic ethanol exposure. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | CEREBRAL GLUCOSE-UTILIZATION ; VENTRAL TEGMENTAL AREA ; CENTRAL-NERVOUS-SYSTEM ; IN-VIVO ; ALCOHOL-DEHYDROGENASE ; POLARIZATION TRANSFER ; METABOLIC TOLERANCE ; MESSENGER-RNA ; ACETALDEHYDE ; ACETATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000323564600074 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/986]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 2.Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06511 USA 3.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06511 USA 4.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jie,Du, Hongying,Jiang, Lihong,et al. Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(35):14444-14449. |
| APA | Wang, Jie.,Du, Hongying.,Jiang, Lihong.,Ma, Xiaoxian.,de Graaf, Robin A..,...&Mason, Graeme F..(2013).Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(35),14444-14449. |
| MLA | Wang, Jie,et al."Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.35(2013):14444-14449. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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