Metabolic Influence of Acute Cyadox Exposure on Kunming Mice
文献类型：期刊论文
| 作者 | Huang, Chongyang1,2,3; Lei, Hehua1,2; Zhao, Xiuju1,2; Tang, Huiru1,2; Wang, Yulan1,2 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2013 |
| 卷号 | 12期号:1页码:537-545 |
| 关键词 | cyadox NMR-based metabonomics multivariate statistical analysis |
| 英文摘要 | Cyadox is an antibiotic drug and has the potential to be used as a feedstuff additive in promoting the growth of animals. However, the toxicity of cyadox should be fully assessed before application, and this has prompted the current investigation on the metabolic responses of mice to cyadox exposure, using a metabonomic technique. Three groups of Kunming mice were respectively given a single dose of cyadox at three different concentrations (100, 650, and 4000 mg/kg body weight) via gavage. We present here the metabolic alterations of urine, plasma, liver, and renal medulla extracts induced by cyadox exposure. The metabolic alterations induced by cyadox exposure are dose-dependent, and metabolic recovery is achieved only for low and moderate levels of cyadox exposure during the experimental period. Cyadox exposure resulted in a disturbance of gut microbiota, which is manifested in depleted levels of urinary hippurate, trimethylamine-N-oxide (TMAO), dimethylamine (DMA), and trimethylamine (TMA). In addition, mice exposed to cyadox at high levels caused accumulations of amino acids and depletions of nucleotides in the liver. Furthermore, marked elevations of nucleotides and a range of organic osmolytes, such as myo-inositol, choline, and glycerophosphocholine (GPC), and decreased levels of amino acids are observed in the renal medulla of cyadox-exposed mice. These results suggest that cyadox exposure causes inhibition of amino acid metabolism in the liver and disturbance of gut microbiota community, influencing osmolytic homeostasis and nucleic acids synthesis in both the liver and the kidney. Our work provides a comprehensive view of the toxicological effects of cyadox, which is important in animal and human food safety. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | GROWTH-PROMOTING AGENTS ; PATTERN-RECOGNITION ; MICRONUCLEUS TEST ; HIPPURIC-ACID ; WISTAR RATS ; METABONOMICS ; TOXICITY ; PIGS ; NMR ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000313156300053 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/998]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Chongyang,Lei, Hehua,Zhao, Xiuju,et al. Metabolic Influence of Acute Cyadox Exposure on Kunming Mice[J]. JOURNAL OF PROTEOME RESEARCH,2013,12(1):537-545. |
| APA | Huang, Chongyang,Lei, Hehua,Zhao, Xiuju,Tang, Huiru,&Wang, Yulan.(2013).Metabolic Influence of Acute Cyadox Exposure on Kunming Mice.JOURNAL OF PROTEOME RESEARCH,12(1),537-545. |
| MLA | Huang, Chongyang,et al."Metabolic Influence of Acute Cyadox Exposure on Kunming Mice".JOURNAL OF PROTEOME RESEARCH 12.1(2013):537-545. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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