The toxicity of acute exposure to T-2 toxin evaluated by the metabonomics technique
文献类型：期刊论文
| 作者 | Wan, Qianfen1,2; Wu, Guangyao3; He, Qinghua1; Tang, Huiru1,4; Wang, Yulan1,5 |
| 刊名 | MOLECULAR BIOSYSTEMS
 |
| 出版日期 | 2015 |
| 卷号 | 11期号:3页码:882-891 |
| 英文摘要 | T-2 toxin is a common contaminant in grains and animal feedstuff, which becomes an increasing threat to human and animal health due to its high toxicity. Investigating the systemic effects of T-2 toxin is important to evaluate the toxicity and facilitate the assessment of food safety. In our investigation, rats were treated with a single dose of T-2 toxin at dosage levels of 0, 0.5, 2.0 and 4.0 mg kg(-1) body weight via gavage. The metabolic profiles of body fluids and multiple organs were obtained by NMR spectroscopy and analyzed by multivariate data analysis methods. The results showed that low and moderate doses of T-2 toxin only influenced the urinary metabonomes, while a high dose of T-2 toxin induced metabolic alterations in urine and multiple organs. These changes included alterations in the levels of membrane metabolites, TCA cycle intermediates, a range of amino acids, nucleosides and nucleotides. T-2 toxin exposure impaired spleen function, causing immunotoxicity, and inhibited protein and DNA biosynthesis. In addition, T-2 toxin also caused oxidative stress and disturbance in energy metabolism and gut microbiome. Our work provided a comprehensive insight into T-2 toxicity and revealed the great potential of metabonomics in assessing the impact of a toxic compound. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | AMINO-ACID-METABOLISM ; LIPID-PEROXIDATION ; IMMUNE-RESPONSE ; LYMPHOID ORGANS ; GROWING-PIGS ; RAT-TISSUES ; IN-VIVO ; MICE ; FUSARIUM ; DNA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349995600021 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1040]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Wuhan 430072, Peoples R China 4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn Biospectroscopy & Metab, Shanghai 200433, Peoples R China 5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Qianfen,Wu, Guangyao,He, Qinghua,et al. The toxicity of acute exposure to T-2 toxin evaluated by the metabonomics technique[J]. MOLECULAR BIOSYSTEMS,2015,11(3):882-891. |
| APA | Wan, Qianfen,Wu, Guangyao,He, Qinghua,Tang, Huiru,&Wang, Yulan.(2015).The toxicity of acute exposure to T-2 toxin evaluated by the metabonomics technique.MOLECULAR BIOSYSTEMS,11(3),882-891. |
| MLA | Wan, Qianfen,et al."The toxicity of acute exposure to T-2 toxin evaluated by the metabonomics technique".MOLECULAR BIOSYSTEMS 11.3(2015):882-891. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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