Antagonist of Prostaglandin E-2 Receptor 4 Induces Metabolic Alterations in Liver of Mice
文献类型：期刊论文
| 作者 | Li, Ning1; Zhang, Limin1; An, Yanpeng2; Zhang, Lulu1; Song, Yipeng1; Wang, Yulan1,3; Tang, Huiru1,2 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 14期号:3页码:1566-1573 |
| 关键词 | prostaglandin E-2 receptor 4 metabonomics transcriptomics NMR L-161982 |
| 英文摘要 | Prostaglandin E-2 receptor 4 (EP4) is one of the receptors for prostaglandin E2 and plays important roles in various biological functions. EP4 antagonists have been used as anti-inflammatory drugs. To investigate the effects of an EP4 antagonist (L-161982) on the endogenous metabolism in a holistic manner, we employed a mouse model, and obtained metabolic and transcriptomic profiles of multiple biological matrixes, including serum, liver, and urine of mice with and without EP4 antagonist (L-161982) exposure. We found that this EP4 antagonist caused significant changes in fatty acid metabolism, choline metabolism, and nucleotide metabolism. EP4 antagonist exposure also induced oxidative stress to mice. Our research is the first of its kind to report information on the alteration of metabolism associated with an EP4 antagonist. This information could further our understanding of current and new biological functions of EP4. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | EP4 RECEPTOR ; H-1-NMR SPECTROSCOPY ; PROSTANOID RECEPTORS ; SYSTEMIC RESPONSES ; DUCTUS-ARTERIOSUS ; ANALYSIS REVEALS ; CANCER CELLS ; RAT-LIVER ; EXPRESSION ; SUBTYPES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350840900022 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1042]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Univ Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 2.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Metab & Syst Biol Lab,Sch Life Sci, Shanghai 200433, Peoples R China 3.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Zhang, Limin,An, Yanpeng,et al. Antagonist of Prostaglandin E-2 Receptor 4 Induces Metabolic Alterations in Liver of Mice[J]. JOURNAL OF PROTEOME RESEARCH,2015,14(3):1566-1573. |
| APA | Li, Ning.,Zhang, Limin.,An, Yanpeng.,Zhang, Lulu.,Song, Yipeng.,...&Tang, Huiru.(2015).Antagonist of Prostaglandin E-2 Receptor 4 Induces Metabolic Alterations in Liver of Mice.JOURNAL OF PROTEOME RESEARCH,14(3),1566-1573. |
| MLA | Li, Ning,et al."Antagonist of Prostaglandin E-2 Receptor 4 Induces Metabolic Alterations in Liver of Mice".JOURNAL OF PROTEOME RESEARCH 14.3(2015):1566-1573. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。