Neural circuits containing olfactory neurons are involved in the prepulse inhibition of the startle reflex in rats
文献类型：期刊论文
| 作者 | Niu, Haichen1,2; He, Xiaobin3,4,5; Zhou, Ting1; Shi, Xi2; Zhang, Qiang1; Zhang, Zhijian3,4; Qiao, Yuehua2; Xu, Fuqiang3,4,5; Hu, Min6 |
| 刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
 |
| 出版日期 | 2015-03-25 |
| 卷号 | 9 |
| 关键词 | olfactory dysfunction sensory stimulus prepulse inhibition (PPI) NMDA receptor neural trace |
| 英文摘要 | Many neuropsychiatric disorders, such as schizophrenia, have been associated with olfactory dysfunction and abnormalities in the prepulse inhibition (PPI) response to a startle reflex. However, whether these two abnormalities could be related is unclear. The present investigations were designed to determine whether theblockage of olfactory sensory input by zinc sulfate infusion in the olfactory naris (0.5 ml, 0.17 M, ZnE) can disturb the PPI response. Furthermore, a bilateral microinjection of lidocaine/MK801 in the olfactory bulb (OB) was administered to examine whether the blockage of olfactory sensory input could impair the PPI response. To identify the neural projection between olfaction and PPI-related areas, trans-synaptic retrograde tracing with the recombinant pseudorabies virus (PRV) was used. Our results demonstrated that blockage of olfactory sensory input could disturb olfactory behavior. In the function studies, we demonstrated that blockage of olfactory sensory input could impair the pre-pulse inhibition of the startle response following decreased c-Fos expression in relevant brain regions during the PPI responses. Furthermore, similar and more robust findings indicated that blockage of olfactory sensory input by microinjection of lidocaine/MK801 in the OB could impair the PPI response. In the circuit-level studies, we demonstrated that trans-synaptic retrograde tracing with PRV exhibited a large portion of labeled neurons in several regions of the olfactory cortices from the pedunculopontine tegmental nucleus (PPTg). Thus, these data suggest that the olfactory system participates in the PPI regulating fields and plays a role in the pre-pulse inhibition of the startle response in rats. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
| 关键词[WOS] | NEUROPSYCHIATRIC DISORDERS ; MICE ; BEHAVIOR ; INACTIVATION ; RECOGNITION ; VASOPRESSIN ; MODULATION ; EXPRESSION ; RESPONSES ; DOPAMINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352285100001 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1058]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Xuzhou Med Coll, Dept Genet, Xuzhou, Peoples R China 2.Xuzhou Collage, Inst Audiol & Speech Sci, Xuzhou, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 5.Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan, Peoples R China 6.Second Peoples Hosp Yunnan Prov, Dept Ophthalmol, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Niu, Haichen,He, Xiaobin,Zhou, Ting,et al. Neural circuits containing olfactory neurons are involved in the prepulse inhibition of the startle reflex in rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2015,9. |
| APA | Niu, Haichen.,He, Xiaobin.,Zhou, Ting.,Shi, Xi.,Zhang, Qiang.,...&Hu, Min.(2015).Neural circuits containing olfactory neurons are involved in the prepulse inhibition of the startle reflex in rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,9. |
| MLA | Niu, Haichen,et al."Neural circuits containing olfactory neurons are involved in the prepulse inhibition of the startle reflex in rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 9(2015). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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