Whole-Brain Mapping of Inputs to Projection Neurons and Cholinergic Interneurons in the Dorsal Striatum
文献类型：期刊论文
| 作者 | Guo, Qingchun1,2; Wang, Daqing3,4; He, Xiaobin5; Feng, Qiru3; Lin, Rui3; Xu, Fuqiang5; Fu, Ling1; Luo, Minmin3,4 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2015-04-01 |
| 卷号 | 10期号:4 |
| 英文摘要 | The dorsal striatum integrates inputs from multiple brain areas to coordinate voluntary movements, associative plasticity, and reinforcement learning. Its projection neurons consist of the GABAergic medium spiny neurons (MSNs) that express dopamine receptor type 1 (D1) or dopamine receptor type 2 (D2). Cholinergic interneurons account for a small portion of striatal neuron populations, but they play important roles in striatal functions by synapsing onto the MSNs and other local interneurons. By combining the modified rabies virus with specific Cre-mouse lines, a recent study mapped the monosynaptic input patterns to MSNs. Because only a small number of extrastriatal neurons were labeled in the prior study, it is important to reexamine the input patterns of MSNs with higher labeling efficiency. Additionally, the whole-brain innervation pattern of cholinergic interneurons remains unknown. Using the rabies virus-based transsynaptic tracing method in this study, we comprehensively charted the brain areas that provide direct inputs to D1-MSNs, D2-MSNs, and cholinergic interneurons in the dorsal striatum. We found that both types of projection neurons and the cholinergic interneurons receive extensive inputs from discrete brain areas in the cortex, thalamus, amygdala, and other subcortical areas, several of which were not reported in the previous study. The MSNs and cholinergic interneurons share largely common inputs from areas outside the striatum. However, innervations within the dorsal striatum represent a significantly larger proportion of total inputs for cholinergic interneurons than for the MSNs. The comprehensive maps of direct inputs to striatal MSNs and cholinergic interneurons shall assist future functional dissection of the striatal circuits. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | TONICALLY ACTIVE NEURONS ; GIANT ASPINY INTERNEURONS ; BASAL GANGLIA ; RAT NEOSTRIATUM ; MOVEMENT-DISORDERS ; MIDBRAIN DOPAMINE ; GENE-EXPRESSION ; RABIES VIRUS ; IN-VIVO ; PATHWAY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352135600143 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1061]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Britton Chance Ctr Biomed Photon, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 2.Huazhong Univ Sci & Technol, Dept Biomed Engn, MoE Key Lab Biomed Photon, Wuhan 430074, Peoples R China 3.Natl Inst Biol Sci, Beijing, Peoples R China 4.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Qingchun,Wang, Daqing,He, Xiaobin,et al. Whole-Brain Mapping of Inputs to Projection Neurons and Cholinergic Interneurons in the Dorsal Striatum[J]. PLOS ONE,2015,10(4). |
| APA | Guo, Qingchun.,Wang, Daqing.,He, Xiaobin.,Feng, Qiru.,Lin, Rui.,...&Luo, Minmin.(2015).Whole-Brain Mapping of Inputs to Projection Neurons and Cholinergic Interneurons in the Dorsal Striatum.PLOS ONE,10(4). |
| MLA | Guo, Qingchun,et al."Whole-Brain Mapping of Inputs to Projection Neurons and Cholinergic Interneurons in the Dorsal Striatum".PLOS ONE 10.4(2015). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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