Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons
文献类型：期刊论文
| 作者 | Wang, Daqing1,2; He, Xiaobing3,4,5; Zhao, Zhe2; Feng, Qiru2; Lin, Rui2; Sun, Yue2; Ding, Ting3,4; Xu, Fuqiang3,4,5,6; Luo, Minmin1,2; Zhan, Cheng2 |
| 刊名 | FRONTIERS IN NEUROANATOMY
 |
| 出版日期 | 2015-03-27 |
| 卷号 | 9 |
| 关键词 | arcuate nucleus POMC neurons nucleus tractus solitarius transsynaptic tracing rabies virus adeno-associated virus |
| 英文摘要 | Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus and nucleus tractus solitarius (NTS) of the brainstem play important roles in suppressing food intake and maintaining energy homeostasis. Previous tract-tracing studies have revealed the axonal connection patterns of these two brain areas, but the intermingling of POMC neurons with other neuron types has made it challenging to precisely identify the inputs and outputs of POMC neurons. In this study, we used the modified rabies virus to map the brain areas that provide direct inputs to the POMC neurons in the ARC and NTS as well as the inputs to the ARC AgRP neurons for comparison. ARC POMC neurons receive inputs from dozens of discrete structures throughout the forebrain and brainstem. The brain areas containing the presynaptic partners of ARC POMC neurons largely overlap with those of ARC AgRP neurons, although POMC neurons receive relatively broader, denser inputs. Furthermore, POMC neurons in the NTS receive direct inputs predominantly from the brainstem and show very different innervation patterns for POMC neurons in the ARC. By selectively expressing fluorescent markers in the ARC and NTS POMC neurons, we found that almost all of their major presynaptic partners are innervated by POMC neurons in the two areas, suggesting that there are strong reciprocal projections among the major POMC neural pathways. By comprehensively chartering the whole-brain connections of the central melanocortin system in a cell-type-specific manner, this study lays the foundation for dissecting the roles and underlying circuit mechanisms of specific neural pathways in regulating energy homeostasis. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Anatomy & Morphology ; Neurosciences |
| 研究领域[WOS] | Anatomy & Morphology ; Neurosciences & Neurology |
| 关键词[WOS] | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS ; ARCUATE NUCLEUS ; PROOPIOMELANOCORTIN NEURONS ; FOOD-INTAKE ; FEEDING-BEHAVIOR ; ENERGY-BALANCE ; SOLITARY TRACT ; SUPRACHIASMATIC NUCLEUS ; EFFERENT PROJECTIONS ; MELANOCORTIN SYSTEM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000352576600001 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1065]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China 2.Natl Inst Biol Sci, Beijing 102206, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Wuhan Natl Lab Optoelect, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Daqing,He, Xiaobing,Zhao, Zhe,et al. Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons[J]. FRONTIERS IN NEUROANATOMY,2015,9. |
| APA | Wang, Daqing.,He, Xiaobing.,Zhao, Zhe.,Feng, Qiru.,Lin, Rui.,...&Zhan, Cheng.(2015).Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons.FRONTIERS IN NEUROANATOMY,9. |
| MLA | Wang, Daqing,et al."Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons".FRONTIERS IN NEUROANATOMY 9(2015). |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。