Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome
文献类型：期刊论文
| 作者 | Zeng, Hao-Long1; Rao, Xiaoping2; Zhang, Lei-Ke1; Zhao, Xiaolu1; Zhang, Wei-Ping1; Wang, Jie2; Xu, Fuqiang2; Guo, Lin1 |
| 刊名 | JOURNAL OF PROTEOMICS
 |
| 出版日期 | 2014-09-23 |
| 卷号 | 109页码:125-142 |
| 关键词 | Olfactory bulb Quantitative proteomics Odor deprivation Odor exposure Metabolic process Synaptic transmission |
| 英文摘要 | Olfactory sensory information is processed and integrated by circuits within the olfactory bulb (OS) before being sent to the olfactory cortex. In the mammalian OB, neural activity driven by external stimuli can lead to experience-dependent changes in structures and functions. In this study, quantitative proteomics techniques were employed to study proteome-wide changes in the OB under four levels of neural activity (from low to high): devoid of peripheral input (using a transgenic model), wild-type control, and short-term and long-term odor exposures. Our results revealed that proteins related to various processes were altered in the OBs of odor-deprived and odor-stimulated mice compared to the wild-type controls. These changes induced by odor stimulation were quite different from those induced by a deficit in peripheral olfactory inputs. Detailed analysis demonstrated that metabolic process and synaptic transmission were the most commonly altered pathways and that the effects of peripheral deprivation were more profound. Our comparative proteomics analysis indicated that olfactory deprivation and odor exposure lead to different alterations in the OB proteome, which provides new dues about the mechanisms underlying the olfactory deprivation- or odor stimulation-induced plasticity of OB function and organization. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | OXIDATIVE-PHOSPHORYLATION ; SYNAPTIC PLASTICITY ; NEURONAL-ACTIVITY ; ODOR DEPRIVATION ; BLOOD-FLOW ; ADULT MICE ; RAT-BRAIN ; EXPOSURE ; MEMORY ; INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345542600011 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1281]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Hao-Long,Rao, Xiaoping,Zhang, Lei-Ke,et al. Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome[J]. JOURNAL OF PROTEOMICS,2014,109:125-142. |
| APA | Zeng, Hao-Long.,Rao, Xiaoping.,Zhang, Lei-Ke.,Zhao, Xiaolu.,Zhang, Wei-Ping.,...&Guo, Lin.(2014).Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome.JOURNAL OF PROTEOMICS,109,125-142. |
| MLA | Zeng, Hao-Long,et al."Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome".JOURNAL OF PROTEOMICS 109(2014):125-142. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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