Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers
文献类型：期刊论文
| 作者 | Li, Bo1,2,4; Gong, Ling1,2,4; Wu, Ruiqi1,2,4; Li, Anan1,2; Xu, Fuqiang1,2,3 |
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2014-07-15 |
| 卷号 | 95页码:29-38 |
| 关键词 | Functional MRI Olfactory bulb Blood oxygenation level dependent (BOLD) Local field potentials (LFP) Layer-dependent |
| 英文摘要 | Blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI), one of the most powerful technologies in neuroscience, measures neural activity indirectly. Therefore, systematic correlation of BOLD signals with other neural activity measurements is critical to understanding and then using the technology. Numerous studies have revealed that the BOLD signal is determined by many factors and is better correlated with local field potentials (LFP) than single/multiple unit firing. The relationship between BOLD and LFP signals under higher spatial resolution is complex and remains unclear. Here, changes of BOLD and LFP signals in the glomerular (GL), mitral cell (MCL), and granular cell layers (GCL) of the olfactory bulb were evoked by odor stimulation and sequentially acquired using high-resolution fMRI and electrode array. The experimental results revealed a rather complex relationship between BOLD and LFP signals. Both signal modalities were increased layer-dependently by odor stimulation, but the orders of signal intensity were significantly different: GL > MCL > GCL and GCL > GL > MCL for BOLD and LFP, respectively. During odor stimulation, the temporal features of LFPs were similar for a given band in different layers, but different for different frequency bands in a given layer. The BOLD and LFP signals in the low gamma frequency band correlated the best. This study provides new evidence for the consistency between structure and function in understanding the neurophysiological basis of BOLD signals, but also reminds that caution must be taken in interpreting of BOLD signals in regard to neural activity. (C) 2014 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | ODORANT MOLECULAR-FEATURES ; INTRINSIC OPTICAL SIGNALS ; FUNCTIONAL MRI ; GAMMA-OSCILLATIONS ; NEURONAL-ACTIVITY ; SPIKING ACTIVITY ; NEURAL ACTIVITY ; BLOOD-FLOW ; RAT ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337267900004 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1284]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Bo,Gong, Ling,Wu, Ruiqi,et al. Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers[J]. NEUROIMAGE,2014,95:29-38. |
| APA | Li, Bo,Gong, Ling,Wu, Ruiqi,Li, Anan,&Xu, Fuqiang.(2014).Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers.NEUROIMAGE,95,29-38. |
| MLA | Li, Bo,et al."Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers".NEUROIMAGE 95(2014):29-38. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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