Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*
文献类型：期刊论文
| 作者 | Coffman, Kimberly1; Yang, Bing2; Lu, Jie1; Tetlow, Ashley L.1; Pelliccio, Emelia1; Lu, Shan2; Guo, Da-Chuan3; Tang, Chun3; Dong, Meng-Qiu2; Tamanoi, Fuyuhiko1 |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2014-02-21 |
| 卷号 | 289期号:8页码:4723-4734 |
| 关键词 | mTOR mTOR Complex (mTORC) Protein Cross-linking Protein Kinases Signaling 4E-BP1 TOS Motif Cross-linking Mass Spectrometry Raptor |
| 英文摘要 | Background: mTORC1 recruits its substrate 4E-BP1 via Raptor/4E-BP1 interaction. Chemical cross-linking/mass spectrometry permits characterization of protein-protein interactions. Results: Cross-linked peptides between Raptor and 4E-BP1 were identified. Raptor intramolecular cross-links were also identified. Conclusion: Raptor N-terminal region containing RNC1 is implicated in the interaction with the central region of 4E-BP1. Significance: Our study provides novel insight into how mTORC1 recognizes 4E-BP1. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TRANSLATION FACTOR EIF4E ; 4E-BINDING PROTEIN ; SIGNALING PATHWAYS ; STRUCTURAL BASIS ; LINKED PEPTIDES ; BINDING PARTNER ; CELL-GROWTH ; MTOR ; INITIATION ; PHOSPHORYLATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000331607900019 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1296]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Univ Calif Los Angeles, Johnsson Comprehens Canc Ctr, Inst Mol Biol, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA 2.Natl Inst Biol Sci, Beijing 102206, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Coffman, Kimberly,Yang, Bing,Lu, Jie,et al. Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2014,289(8):4723-4734. |
| APA | Coffman, Kimberly.,Yang, Bing.,Lu, Jie.,Tetlow, Ashley L..,Pelliccio, Emelia.,...&Tamanoi, Fuyuhiko.(2014).Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*.JOURNAL OF BIOLOGICAL CHEMISTRY,289(8),4723-4734. |
| MLA | Coffman, Kimberly,et al."Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*".JOURNAL OF BIOLOGICAL CHEMISTRY 289.8(2014):4723-4734. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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