Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection
文献类型：期刊论文
| 作者 | Zhu, Xiaoyang1,5; Lei, Hehua1; Wu, Junfang1; Li, Jia V.3; Tang, Huiru1,2; Wang, Yulan1,4 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2014-10-01 |
| 卷号 | 13期号:10页码:4436-4445 |
| 关键词 | infectious disease itaconic acid metabonomics NMR Salmonella typhimurium |
| 英文摘要 | Salmonella typhimurium is a bacterial pathogen that poses a great threat to humans and animals. In order to discover hosts responses to S. typhimurium infection, we collected and analyzed biofluids and organ tissues from mice which had ingested S. typhimurium. We employed H-1 NMR spectroscopy coupled with multivariate data analysis and immunological techniques. The results indicate that infection leads to a severe impact on mice spleen and ileum, which are characterized by splenomegaly and edematous villi, respectively. We found that increased levels of itaconic acid were correlated with the presence of splenomegaly during infection and may play an important role in Salmonella-containing vacuole acidification. In addition, metabonomic analyses of urine displayed the development of salmonellosis in mice, which is characterized by dynamic changes in energy metabolism. Furthermore, we found that the presence of S. typhimurium activated an anti-oxidative response in infected mice. We also observed changes in the gut microbial co-metabolites (hippurate, TMAO, TMA, methylamine). This investigation sheds much needed light on the hostpathogen interactions of S. typhimurium, providing further information to deepen our understanding of the long co-evolution process between hosts and infective bacteria. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TAURINE TRANSPORTER EXPRESSION ; CORNEAL EPITHELIAL-CELLS ; NITRIC-OXIDE SYNTHESIS ; III SECRETION SYSTEM ; ISOCITRATE LYASE ; SEROVAR TYPHIMURIUM ; ITACONIC ACID ; MOUSE MODEL ; MYCOBACTERIUM-TUBERCULOSIS ; CONTAINING VACUOLE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342719200019 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1392]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance,Key Lab Magnet Resonan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn Biospect & Metabol, Shanghai 200433, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Surg & Canc, London SW7 2AZ, England 4.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Xiaoyang,Lei, Hehua,Wu, Junfang,et al. Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection[J]. JOURNAL OF PROTEOME RESEARCH,2014,13(10):4436-4445. |
| APA | Zhu, Xiaoyang,Lei, Hehua,Wu, Junfang,Li, Jia V.,Tang, Huiru,&Wang, Yulan.(2014).Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection.JOURNAL OF PROTEOME RESEARCH,13(10),4436-4445. |
| MLA | Zhu, Xiaoyang,et al."Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection".JOURNAL OF PROTEOME RESEARCH 13.10(2014):4436-4445. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。