Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice
文献类型：期刊论文
| 作者 | Chen, Yanmei1; Liu, Xiaofen4; Jia, Xianglei1; Zong, Wei2,3; Ma, Yuanye2,3; Xu, Fuqiang5; Wang, Jianhong2,3 |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2014-12-15 |
| 卷号 | 275页码:219-224 |
| 关键词 | Olfactory Depression Anxiety Olfactory deficient |
| 英文摘要 | There is a close neuroanatomical connection between odor and emotional processing. Olfactory dysfunction is found in various neurodegenerative and neuropsychiatric disorders. Here, mice take the cyclic nucleotide gated channel 2 mutant gene (Cnga2), which is critical for olfactory sensory neurons to generate odor induced action potentials were used. The Cnga2 mice were congenitally anosmic. Adult mice were tested in a series behavioral paradigm such as open field, light/dark box, forced swim test and Y-maze. Our study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings. However, Cnga2 mice showed no difference from the wide types when tested in the two-trial recognition Y-maze. The results indicate that innate olfactory deficiency might modulate emotional behaviors in mice. (C) 2014 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
| 关键词[WOS] | CONDITIONED PLACE PREFERENCE ; SPATIAL RECOGNITION MEMORY ; MATERNAL SEPARATION ; MAJOR DEPRESSION ; PSYCHIATRIC-DISORDERS ; PIRIFORM CORTEX ; VISUAL-CORTEX ; BULB ; DEPRIVATION ; RAT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344431100029 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1441]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Kunming Univ Sci & Technol, Fac Med, Kunming 650550, Yunnan, Peoples R China 2.Chinese Acad Sci, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Yunnan Prov Kunming Inst Zool, Kunming 650223, Peoples R China 4.Bengbu Med Coll, Dept Physiol, Bengbu 233030, Anhui, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430007, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yanmei,Liu, Xiaofen,Jia, Xianglei,et al. Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice[J]. BEHAVIOURAL BRAIN RESEARCH,2014,275:219-224. |
| APA | Chen, Yanmei.,Liu, Xiaofen.,Jia, Xianglei.,Zong, Wei.,Ma, Yuanye.,...&Wang, Jianhong.(2014).Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice.BEHAVIOURAL BRAIN RESEARCH,275,219-224. |
| MLA | Chen, Yanmei,et al."Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice".BEHAVIOURAL BRAIN RESEARCH 275(2014):219-224. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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