Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury
文献类型：期刊论文
| 作者 | Chen, Tao1,2,3,4; Koga, Kohei1,4; Descalzi, Giannina4; Qiu, Shuang1,4; Wang, Jian2,3; Zhang, Le-Shi2,3; Zhang, Zhi-Jian5,6,7; He, Xiao-Bin5,8; Qin, Xin9; Xu, Fu-Qiang5,6,7,8 |
| 刊名 | MOLECULAR PAIN
 |
| 出版日期 | 2014-06-03 |
| 卷号 | 10 |
| 英文摘要 | Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. In the anterior cingulate cortex (ACC), postsynaptic recruitment or modification of AMPA receptor (AMPAR) GluA1 contribute to the expression of LTP. Here we report that pyramidal cells in the deep layers of the ACC send direct descending projecting terminals to the dorsal horn of the spinal cord (lamina I-III). After peripheral nerve injury, these projection cells are activated, and postsynaptic excitatory responses of these descending projecting neurons were significantly enhanced. Newly recruited AMPARs contribute to the potentiated synaptic transmission of cingulate neurons. PKA-dependent phosphorylation of GluA1 is important, since enhanced synaptic transmission was abolished in GluA1 phosphorylation site serine-845 mutant mice. Our findings provide strong evidence that peripheral nerve injury induce long-term enhancement of cortical-spinal projecting cells in the ACC. Direct top-down projection system provides rapid and profound modulation of spinal sensory transmission, including painful information. Inhibiting cortical top-down descending facilitation may serve as a novel target for treating neuropathic pain. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | AMPA-RECEPTOR TRAFFICKING ; LONG-TERM POTENTIATION ; IN-VIVO EXPERIENCE ; SPINAL NOCICEPTIVE TRANSMISSION ; GIGANTOCELLULARIS-PARS-ALPHA ; STIMULATED ADENYLYL CYCLASES ; DESCENDING FACILITATION ; SYNAPTIC PLASTICITY ; PYRAMIDAL NEURONS ; NEUROPATHIC PAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338146100001 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1500]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Xi An Jiao Tong Univ, Ctr Neuron & Dis, Frontier Inst Sci & Technol, Xian 710049, Peoples R China 2.Fourth Mil Med Univ, Dept Anat Histol & Embryol, Xian 710032, Peoples R China 3.Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China 4.Univ Toronto, Fac Med, Ctr Study Pain, Dept Physiol, Toronto, ON M5S 1A8, Canada 5.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 6.Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 7.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 9.Wuhan Univ, Coll Life Sci, Wuhan 430071, Peoples R China 10.Univ Maryland, Sch Dent, Dept Biomed Sci, Baltimore, MD 21201 USA |
| 推荐引用方式 GB/T 7714 | Chen, Tao,Koga, Kohei,Descalzi, Giannina,et al. Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury[J]. MOLECULAR PAIN,2014,10. |
| APA | Chen, Tao.,Koga, Kohei.,Descalzi, Giannina.,Qiu, Shuang.,Wang, Jian.,...&Zhuo, Min.(2014).Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury.MOLECULAR PAIN,10. |
| MLA | Chen, Tao,et al."Postsynaptic potentiation of corticospinal projecting neurons in the anterior cingulate cortex after nerve injury".MOLECULAR PAIN 10(2014). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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