The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment
文献类型：期刊论文
| 作者 | Li, Hongde1,6; Zhu, Wandi2,6; Zhang, Leike3; Lei, Hehua1; Wu, Xiangyu1,6; Guo, Lin3; Chen, Xinwen2; Wang, Yulan1,5; Tang, Huiru1,4 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-02-12 |
| 卷号 | 5 |
| 英文摘要 | Chronic infection caused by the hepatitis B virus (HBV), is strongly associated with hepatitis, fatty liver and hepatocellular carcinoma. To investigate the underlying mechanisms, we characterize the metabolic features of host cells infected with the virus using systems biological approach. The results show that HBV replication induces systematic metabolic alterations in host cells. HBV infection up-regulates the biosynthesis of hexosamine and phosphatidylcholine by activating glutamine-fructose-6-phosphate amidotransferase 1 (GFAT1) and choline kinase alpha (CHKA) respectively, which were reported for the first time for HBV infection. Importantly suppressing hexosamine biosynthesis and phosphatidylcholine biosynthesis can inhibit HBV replication and expression. In addition, HBV induces oxidative stress and stimulates central carbon metabolism and nucleotide synthesis. Our results also indicate that HBV associated hepatocellular carcinoma could be attributed to GFAT1 activated hexosamine biosynthesis and CHKA activated phosphatidylcholine biosynthesis. This study provides further insights into the pathogenesis of HBV-induced diseases, and sheds new light on drug target for treating HBV infection. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | FATTY-ACID SYNTHASE ; CHOLINE KINASE ; IN-VIVO ; HYDROGEN-PEROXIDE ; GENE-EXPRESSION ; TRANSGENIC MICE ; O-GLCNAC ; MALIGNANT-TRANSFORMATION ; HEPATOCELLULAR-CARCINOMA ; CELL-PROLIFERATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349245600020 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1523]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 3.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China 4.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Metabol & Syst Biol Lab,Sch Life Sci, Shanghai 200433, Peoples R China 5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hongde,Zhu, Wandi,Zhang, Leike,et al. The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Li, Hongde.,Zhu, Wandi.,Zhang, Leike.,Lei, Hehua.,Wu, Xiangyu.,...&Tang, Huiru.(2015).The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment.SCIENTIFIC REPORTS,5. |
| MLA | Li, Hongde,et al."The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment".SCIENTIFIC REPORTS 5(2015). |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。