ECR-MAPK Regulation in Liver Early Development
文献类型：期刊论文
| 作者 | Zhao, Xiu-Ju1,2; Zhuo, Hexian3 |
| 刊名 | BIOMED RESEARCH INTERNATIONAL
 |
| 出版日期 | 2014 |
| 英文摘要 | Early growth is connected to a key link between embryonic development and aging. In this paper, liver gene expression profiles were assayed at postnatal day 22 and week 16 of age. Meanwhile another independent animal experiment and cell culture were carried out for validation. Significance analysis of microarrays, qPCR verification, drug induction/inhibition assays, and metabonomics indicated that alpha-2u globulin (extracellular region)-socs2 (-SH2-containing signals/receptor tyrosine kinases)-ppp2r2a/pik3c3 (MAPK signaling)-hsd3b5/cav2 (metabolism/organization) plays a vital role in early development. Taken together, early development of male rats is ECR and MAPK-mediated coordination of cancer-like growth and negative regulations. Our data represent the first comprehensive description of early individual development, which could be a valuable basis for understanding the functioning of the gene interaction network of infant development. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 关键词[WOS] | HEPATIC GENE-EXPRESSION ; MICROARRAY DATA ; SPECTROSCOPY ; ACTIVATION ; RECEPTOR ; CXCL13 ; CANCER ; MODEL ; DIET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000347793700001 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1536]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Collaborat Innovat Ctr Proc Agr Prod Hubei Prov, Wuhan 430023, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Xinxiang Inst Drug Control, Xinxiang 453000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xiu-Ju,Zhuo, Hexian. ECR-MAPK Regulation in Liver Early Development[J]. BIOMED RESEARCH INTERNATIONAL,2014. |
| APA | Zhao, Xiu-Ju,&Zhuo, Hexian.(2014).ECR-MAPK Regulation in Liver Early Development.BIOMED RESEARCH INTERNATIONAL. |
| MLA | Zhao, Xiu-Ju,et al."ECR-MAPK Regulation in Liver Early Development".BIOMED RESEARCH INTERNATIONAL (2014). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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