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Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice
文献类型：期刊论文
| 作者 | Zhao, Ying1,2; Wu, Junfang2; Li, Jia V.3; Zhou, Ning-Yi4; Tang, Huiru2; Wang, Yulan2,5 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 12期号:6页码:2987-2999 |
| 关键词 | gut microbiota antibiotics NMR PCR-DGGE fecal extracts metabonomics |
| 英文摘要 | The gut microbiome is known to be extensively involved in human health and disease. In order to reveal the metabolic relationship between host and microbiome, we monitored recovery of the gut microbiota composition and fecal profiles of mice after gentamicin and/or ceftriaxone treatments. This was performed by employing nuclear magnetic resonance (NMR)-based metabonomics and denaturing gradient gel electrophoresis (DGGE) fingerprint of gut microbiota. The common features of fecal metabolites postantibiotic treatment include decreased levels of short chain fatty acids (SCFAs), amino acids and primary bile acids and increased oligosaccharides, D-pinitol, choline and secondary bile acids (deoxycholic acid). This suggests suppressed bacterial fermentation, protein degradation and enhanced gut microbial modification of bile acids. Barnesiella, Prevotella, and Alistipes levels were shown to decrease as a result of the antibiotic treatment, whereas levels of Bacteroides, Enterococcus and Erysipelotrichaceae incertae sedis, and Mycoplasma increased after gentamicin and ceftriaxone treatment. In addition, there was a strong correlation between fecal profiles and levels of Bacteroides, Barnesiella, Alistipes and Prevotella. The integration of metabonomics and gut microbiota profiling provides important information on the changes of gut microbiota and their impact on fecal profiles during the recovery after antibiotic treatment. The correlation between gut microbiota and fecal metabolites provides important information on the function of bacteria, which in turn could be important in optimizing therapeutic strategies, and developing potential microbiota-based disease preventions and therapeutic interventions. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | ECHINOSTOMA-CAPRONI INFECTION ; INFLAMMATORY-BOWEL-DISEASE ; AMINO-ACID-METABOLISM ; SYSTEMS BIOLOGY ; INTESTINAL MICROBIOTA ; METAGENOMIC ANALYSIS ; DEOXYCHOLIC-ACID ; NMR-SPECTROSCOPY ; MOUSE MODEL ; BILE-ACID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000320298600056 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1540]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Life Sci & Technol, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London SW7 2AZ, England 4.Chinese Acad Sci, Key Lab Agr & Environm Microbiol, Wuhan Inst Virol, Wuhan 430071, Peoples R China 5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Ying,Wu, Junfang,Li, Jia V.,et al. Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice[J]. JOURNAL OF PROTEOME RESEARCH,2013,12(6):2987-2999. |
| APA | Zhao, Ying,Wu, Junfang,Li, Jia V.,Zhou, Ning-Yi,Tang, Huiru,&Wang, Yulan.(2013).Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice.JOURNAL OF PROTEOME RESEARCH,12(6),2987-2999. |
| MLA | Zhao, Ying,et al."Gut Microbiota Composition Modifies Fecal Metabolic Profiles in Mice".JOURNAL OF PROTEOME RESEARCH 12.6(2013):2987-2999. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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