Targeting the Human Genome-Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine
文献类型：期刊论文
| 作者 | Zhao, Liping1; Nicholson, Jeremy K.2; Lu, Aiping3; Wang, Zhengtao4; Tang, Huiru5; Holmes, Elaine2; Shen, Jian1; Zhang, Xu1; Li, Jia V.2; Lindon, John C.2 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 11期号:7页码:3509-3519 |
| 关键词 | drug discovery global systems biology gut microbiome superorganism traditional Chinese medicine |
| 英文摘要 | Most chronic diseases impairing current human public health involve not only the human genome but also gene environment interactions, and in the latter case the gut microbiome is an important factor. This makes the classical single drug receptor target drug discovery paradigm much less applicable. There is widespread and increasing international interest in understanding the properties of traditional Chinese medicines (TCMs) for their potential utilization as a source of new drugs for Western markets as emerging evidence indicates that most TCM drugs are actually targeting both the host and its symbiotic microbes. In this review, we explore the challenges of and opportunities for harmonizing Eastern-Western drug discovery paradigms by focusing on emergent functions at the whole body level of humans as superorganisms. This could lead to new drug candidate compounds for chronic diseases targeting receptors outside the currently accepted "druggable genome" and shed light on current high interest issues in Western medicine such as drug drug and drug diet gut microbial interactions that will be crucial in the development and delivery of future therapeutic regimes optimized for the individual patient. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | ACUTE PROMYELOCYTIC LEUKEMIA ; GUT MICROBIOTA ; MASS-SPECTROMETRY ; NMR-SPECTROSCOPY ; INSULIN-RESISTANCE ; ARSENIC TRIOXIDE ; DATA SETS ; METABONOMICS ; INFLAMMATION ; OBESITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306049800001 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1553]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China 2.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, Fac Med, London SW7 2AZ, England 3.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China 4.Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Inst Chinese Mat Med, Shanghai 201210, Peoples R China 5.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Ctr Biospect & Metabon, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Liping,Nicholson, Jeremy K.,Lu, Aiping,et al. Targeting the Human Genome-Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(7):3509-3519. |
| APA | Zhao, Liping.,Nicholson, Jeremy K..,Lu, Aiping.,Wang, Zhengtao.,Tang, Huiru.,...&Lindon, John C..(2012).Targeting the Human Genome-Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine.JOURNAL OF PROTEOME RESEARCH,11(7),3509-3519. |
| MLA | Zhao, Liping,et al."Targeting the Human Genome-Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine".JOURNAL OF PROTEOME RESEARCH 11.7(2012):3509-3519. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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