Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach
文献类型：期刊论文
| 作者 | He, Qinghua1,2,3,4; Ren, Pingping1; Kong, Xiangfeng2,3,4; Wu, Yongning5; Wu, Guoyao2,3,4,6; Li, Peng6; Hao, Fuhua1 ; Tang, Huiru1; Blachier, Francois7; Yin, Yulong2,3,4
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| 刊名 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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| 出版日期 | 2012-02-01 |
| 卷号 | 23期号:2页码:133-139 |
| 关键词 | Metabonomics Obese pigs Lean pigs Obesity Serum |
| 英文摘要 | Childhood obesity has become a prevalent risk to health of children and teenagers. To develop biomarkers in serum for altered lipid metabolism, genetically obese (Ningxiang strain) and lean (DurocxLandracexLarge Yorkshire strain) growing pigs were used as models to identify potential differences in the serum metabonome between the two strains of pigs after consuming the same diet for 46 days. At the end of the study, pigs were euthanized for analysis of the serum metabonome and determination of body composition. Obese pigs had higher fat mass (42.3 +/- 8.8% vs. 21.9 +/- 4.5%) and lower muscle mass (35.4 +/- 4.5% vs. 58.9 +/- 2.5%) than lean pigs (P<.01). Serum concentrations of insulin and glucagon were higher (P<.02) in obese than in lean pigs. With the use of an NMR-based metabonomic technology, orthogonal projection to latent structure with discriminant analysis showed that serum HDL, VLDL, lipids, unsaturated lipids, glycoprotein, myo-inositol, pyruvate, threonine, tyrosine and creatine were higher in obese than in lean pigs (P<.05), while serum glucose and urea were lower in obese pigs (P<.05). In addition, changes in gut microbiota-related metabolites, including trimethylamine-N-oxide and choline, were observed in sera of obese pigs relatively to lean pigs (P<.05). These novel findings indicate that obese pigs have distinct metabolism, including lipogenesis, lipid oxidation, energy utilization and partition, protein and amino acid metabolism, and fermentation of gastrointestinal microbes, compared with lean pigs. The obese Ningxiang pig may be a useful model for childhood obesity research. (C) 2012 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 关键词[WOS] | MULTIVARIATE DATA-ANALYSIS ; DIABETIC FATTY RATS ; CHILDHOOD OBESITY ; H-1-NMR SPECTROSCOPY ; INSULIN-RESISTANCE ; ANIMAL-MODELS ; AMINO-ACIDS ; PLASMA ; SUPPLEMENTATION ; PHENOTYPES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299457600005 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1558]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 2.Chinese Acad Sci, Res Ctr Hlth Breeding Livestock & Poultry, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China 3.Chinese Acad Sci, Res Ctr Anim & Poultry Sci, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China 4.Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China 5.Chinese CDC, Natl Inst Nutr & Food Safety, Beijing 100050, Peoples R China 6.Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA 7.Natl Inst Agr Res INRA France, USC INRA AgroParisTech 914, F-75005 Paris, France |
| 推荐引用方式 GB/T 7714 | He, Qinghua,Ren, Pingping,Kong, Xiangfeng,et al. Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2012,23(2):133-139. |
| APA | He, Qinghua.,Ren, Pingping.,Kong, Xiangfeng.,Wu, Yongning.,Wu, Guoyao.,...&Yin, Yulong.(2012).Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,23(2),133-139. |
| MLA | He, Qinghua,et al."Comparison of serum metabolite compositions between obese and lean growing pigs using an NMR-based metabonomic approach".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 23.2(2012):133-139. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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