Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways
文献类型：期刊论文
| 作者 | Liu, Yansong1; Xu, Dan1,2; Feng, Jianghua3,4; Kou, Hao1; Liang, Gai1; Yu, Hong2; He, Xiaohua2; Zhang, Baifang2; Chen, Liaobin2; Magdalou, Jacques5 |
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 |
| 出版日期 | 2012-07-15 |
| 卷号 | 262期号:2页码:205-216 |
| 关键词 | Caffeine Intrauterine growth retardation Metabonome Glucocorticoid Intrauterine programming |
| 英文摘要 | The aims of this study were to clarify the metabonome alteration in fetal rats after prenatal caffeine ingestion and to explore the underlying mechanism pertaining to the increased fetal circulatory glucocorticoid (GC). Pregnant Wistar rats were daily intragastrically administered with different doses of caffeine (0, 20, 60 and 180 mg/kg) from gestational days (GD) 11 to 20. Metabonome of fetal plasma and amniotic fluid on GD20 were analyzed by H-1 nuclear magnetic resonance-based metabonomics. Gene and protein expressions involved in the GC metabolism, glucose and lipid metabolic pathways in fetal liver and gastrocnemius were measured by real-time RT-PCR and immunohistochemistry. Fetal plasma metabonome were significantly altered by caffeine, which presents as the elevated alpha- and beta-glucose, reduced multiple lipid contents, varied apolipoprotein contents and increased levels of a number of amino acids. The metabonome of amniotic fluids showed a similar change as that in fetal plasma. Furthermore, the expressions of 11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD-2) were decreased, while the level of blood GC and the expressions of 11 beta-HSD-1 and glucocorticoid receptor (GR) were increased in fetal liver and gastrocnemius. Meanwhile, the expressions of insulin-like growth factor 1 (IGF-1), IGF-1 receptor and insulin receptor were decreased, while the expressions of adiponectin receptor 2, leptin receptors and AMP-activated protein kinase alpha 2 were increased after caffeine treatment. Prenatal caffeine ingestion characteristically change the fetal metabonome, which is probably attributed to the alterations of glucose and lipid metabolic pathways induced by increased circulatory GC, activated GC metabolism and enhanced GR expression in peripheral metabolic tissues. (C) 2012 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | INTRAUTERINE GROWTH RESTRICTION ; INSULIN-RESISTANCE ; PPAR-GAMMA ; ADIPONECTIN ; LEPTIN ; EXPRESSION ; RECEPTOR ; EXPOSURE ; OBESITY ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000305845400012 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1569]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China 2.Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 4.Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China 5.Nancy Univ, CNRS, UMR 7561, Fac Med, Vandoeuvre Les Nancy, France |
| 推荐引用方式 GB/T 7714 | Liu, Yansong,Xu, Dan,Feng, Jianghua,et al. Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2012,262(2):205-216. |
| APA | Liu, Yansong.,Xu, Dan.,Feng, Jianghua.,Kou, Hao.,Liang, Gai.,...&Wang, Hui.(2012).Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways.TOXICOLOGY AND APPLIED PHARMACOLOGY,262(2),205-216. |
| MLA | Liu, Yansong,et al."Fetal rat metabonome alteration by prenatal caffeine ingestion probably due to the increased circulatory glucocorticoid level and altered peripheral glucose and lipid metabolic pathways".TOXICOLOGY AND APPLIED PHARMACOLOGY 262.2(2012):205-216. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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