Metabolic Response to Klebsiella pneumoniae Infection in an Experimental Rat Model
文献类型：期刊论文
| 作者 | Dong, Fangcong1,3; Wang, Bin2; Zhang, Lulu1,3; Tang, Huiru1; Li, Jieshou2; Wang, Yulan1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2012-11-30 |
| 卷号 | 7期号:11 |
| 英文摘要 | Bacteremia, the presence of viable bacteria in the blood stream, is often associated with several clinical conditions. Bacteremia can lead to multiple organ failure if managed incorrectly, which makes providing suitable nutritional support vital for reducing bacteremia-associated mortality. In order to provide such information, we investigated the metabolic consequences of a Klebsiella pneumoniae (K. pneumoniae) infection in vivo by employing a combination of 1 H nuclear magnetic resonance spectroscopy and multivariate data analysis. K. pneumoniae was intravenously infused in rats; urine and plasma samples were collected at different time intervals. We found that K. pneumoniae-induced bacteremia stimulated glycolysis and the tricarboxylic acid cycle and also promoted oxidation of fatty acids and creatine phosphate to facilitate the energy-demanding host response. In addition, K. pneumoniae bacteremia also induced anti-endotoxin, anti-inflammatory and anti-oxidization responses in the host. Furthermore, bacteremia could cause a disturbance in the gut microbiotal functions as suggested by alterations in a range of amines and bacteria-host co-metabolites. Our results suggest that supplementation with glucose and a high-fat and choline-rich diet could ameliorate the burdens associated with bacteremia. Our research provides underlying pathological processes of bacteremia and a better understanding of the clinical and biochemical manifestations of bacteremia. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | POLYUNSATURATED FATTY-ACIDS ; RISK-FACTORS ; BACTEREMIA ; INFLAMMATION ; LIPOPROTEINS ; PLASMA ; MICE ; METABONOMICS ; HOST ; ENDOTOXIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000312376100268 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1593]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan, Peoples R China 2.Jinling Hosp, Res Inst Gen Surg, Nanjing, Jiangsu, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Fangcong,Wang, Bin,Zhang, Lulu,et al. Metabolic Response to Klebsiella pneumoniae Infection in an Experimental Rat Model[J]. PLOS ONE,2012,7(11). |
| APA | Dong, Fangcong,Wang, Bin,Zhang, Lulu,Tang, Huiru,Li, Jieshou,&Wang, Yulan.(2012).Metabolic Response to Klebsiella pneumoniae Infection in an Experimental Rat Model.PLOS ONE,7(11). |
| MLA | Dong, Fangcong,et al."Metabolic Response to Klebsiella pneumoniae Infection in an Experimental Rat Model".PLOS ONE 7.11(2012). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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