Metabonomic Analysis Reveals the CCl4-Induced Systems Alterations for Multiple Rat Organs
文献类型：期刊论文
| 作者 | Jiang, Limiao1,2; Huang, Jing1; Wang, Yulan1; Tang, Huiru1 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2012-07-01 |
| 卷号 | 11期号:7页码:3848-3859 |
| 关键词 | carbon tetrachloride metabonomics systems toxicity rat organs NMR |
| 英文摘要 | CCl4-induced metabonomic changes have been extensively studied for mammalian liver, and such changes have not been reported for other organs. To investigate the CCl4 effects on other organs, we analyzed the CCl4-induced metabonomic changes in rat kidney, lung, and spleen using H-1 NMR-based metabonomics approaches with complementary information on serum clinical chemistry and histopathology. We found that acute CCl4 exposure caused significant level elevation for creatine and decline for glucose, taurine, trimethylamine, uridine, and adenosine in rat kidney. CCl4-treatment also induced elevation of amino acids (isoleucine, leucine, valine, threonine, alanine, lysine, ornithine, methionine, tyrosine, phenylalanine, and histidine), creatine, and betaine in rat lung together with depletion of glycogen, glucose, taurine, glycine, and hypoxanthine. Furthermore, CCl4 caused elevation of lactate, alanine, betaine, and uracil in rat spleen accompanied with decline for glucose, choline, and hypoxanthine. These observations indicated that CCl4 caused oxidative stresses to multiple rat organs and alterations of their functions including renal osmotic regulations, accelerated glycolysis, and protein and nucleotide catabolism. These findings provide essential information on CCl4 toxicity to multiple rat organs and suggest that systems toxicological views are required for metabonomic studies of toxins by taking many other organs into consideration apart from so-called targeted ones. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | MAGNETIC-RESONANCE-SPECTROSCOPY ; CARBON-TETRACHLORIDE INTOXICATION ; KIDNEY GLUCOSE-6-PHOSPHATASE ; INDUCED HEPATOTOXICITY ; H-1-NMR SPECTROSCOPY ; METABOLIC-ACTIVATION ; HYDRAZINE TOXICITY ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; LUNG INJURY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306049800029 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1607]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance,Ctr Biospect & Metabon, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Limiao,Huang, Jing,Wang, Yulan,et al. Metabonomic Analysis Reveals the CCl4-Induced Systems Alterations for Multiple Rat Organs[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(7):3848-3859. |
| APA | Jiang, Limiao,Huang, Jing,Wang, Yulan,&Tang, Huiru.(2012).Metabonomic Analysis Reveals the CCl4-Induced Systems Alterations for Multiple Rat Organs.JOURNAL OF PROTEOME RESEARCH,11(7),3848-3859. |
| MLA | Jiang, Limiao,et al."Metabonomic Analysis Reveals the CCl4-Induced Systems Alterations for Multiple Rat Organs".JOURNAL OF PROTEOME RESEARCH 11.7(2012):3848-3859. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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