An ethanol vapor chamber system for small animals
文献类型：期刊论文
| 作者 | Wang, Jie1,3; Jiang, Lihong3; Du, Hongying3,4; Mason, Graeme F.2,3 |
| 刊名 | JOURNAL OF NEUROSCIENCE METHODS
 |
| 出版日期 | 2012-06-30 |
| 卷号 | 208期号:1页码:79-85 |
| 关键词 | Ethanol vapor chamber Ethanol administration Rats Alcohol |
| 英文摘要 | Ethanol vapor chambers have been utilized widely in alcohol research since their introduction in 1971, and implementations of these systems are now available commercially. Here, we present a modification of the chamber that can be built at lower cost and greater simplicity of operation. The six-chamber system for rats has multiple air pumps. Ethanol vapor levels are adjusted with the air flow rate, ethanol drip rate, and dilution with room air, without a heater or fans. Ethanol vapor concentrations are measured with a breathalyzer, using room air to dilute the vapor chamber output into the range of the breathalyzer. Multiple pumps provide backup to ensure animal survival in the case of failure of the primary air pump. Tests in animals demonstrated comfortable and stable elevation of blood ethanol, with tight control of the ethanol vapor concentrations and the ability to select from a broad range of levels. The ethanol vapor measurement was rapid and efficient. The parts cost was a few thousand U.S. dollars. This vapor chamber system features low cost, ease of use, and convenient and inexpensive measurement of ethanol vapor concentrations. The lack of a heater and electrical components that could come into contact with ethanol in our case facilitated institutional approval. (C) 2012 Elsevier BM. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | PHYSICAL-DEPENDENCE ; RATS ; ALCOHOL ; WITHDRAWAL ; INHALATION ; EXPOSURE ; MICE ; BRAIN ; BLOOD |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000305865600010 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1672]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 2.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA 3.Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06519 USA 4.Lanzhou Univ, Sch Publ Hlth, Lanzhou 073000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jie,Jiang, Lihong,Du, Hongying,et al. An ethanol vapor chamber system for small animals[J]. JOURNAL OF NEUROSCIENCE METHODS,2012,208(1):79-85. |
| APA | Wang, Jie,Jiang, Lihong,Du, Hongying,&Mason, Graeme F..(2012).An ethanol vapor chamber system for small animals.JOURNAL OF NEUROSCIENCE METHODS,208(1),79-85. |
| MLA | Wang, Jie,et al."An ethanol vapor chamber system for small animals".JOURNAL OF NEUROSCIENCE METHODS 208.1(2012):79-85. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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