gamma-MPS-Modified Silica Conical Microcolumn Separation/Preconcentration of Trace Antipsychotic Drugs in Rat Plasma and Environmental Water Samples Prior to Their Determination by LC
文献类型：期刊论文
| 作者 | Yang, Tonghua1; Cai, Peishan1; Li, Dan1; Chen, Jing1; Xiong, Chaomei1; Ruan, Jinlan1; Wang, Liying2 |
| 刊名 | CHROMATOGRAPHIA
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 77期号:23-24页码:1623-1632 |
| 关键词 | Column liquid chromatography gamma-Methacryloxypropyltrimethoxysilane-modified silica Antipsychotic drugs Rat plasma Environmental water |
| 英文摘要 | A conical microcolumn packed with gamma-methacryloxypropyltrimethoxysilane (gamma-MPS)-modified silica particles was developed for the separation/preconcentration of trace carbamazepine, amitriptyline, quetiapine, clozapine, clomipramine, and thioridazine in rat plasma and environmental water samples followed by liquid chromatography method coupled with ultra-violet detector. The chromatographic analysis was performed on a C-18 column under optimal conditions (mobile phase: ammonium acetate (0.03 mol L-1)-methanol-acetonitrile (37.0:44.1:18.9, v/v/v); flow rate: 1.0 mL min(-1); detection wavelength: 238 nm; column temperature: 25 A degrees C). The prepared gamma-MPS-modified silica particles were characterized by Fourier transform infrared spectroscopy and a Varian Infinity-plus400 NMR spectrometer. Various influencing factors such as pH, elution solvent and volume, flow rate and sample volume were investigated systematically. Under the optimal conditions, the method detection limits and the limits of quantitation were 0.7 and 2.1 ng mL(-1) for carbamazepine, 0.4 and 1.3 ng mL(-1) for amitriptyline, 0.6 and 1.8 ng mL(-1) for quetiapine, 0.7 and 2.1 ng mL(-1) for clozapine, 1.5 and 4.7 ng mL(-1) for clomipramine, 0.8 and 2.6 ng mL(-1) for thioridazine, respectively. The relative standard deviations for six replicates of analytes at 0.050 A mu g mL(-1) were less than 4.1 %. The proposed method was applied to the determination of trace amounts of the analytes in the spiked rat plasma and environmental water samples with satisfactory recoveries. It showed wide potential application in the field of the analysis of pharmaceuticals in real environmental water samples and the therapeutic drug monitoring. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Chemistry, Analytical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | SOLID-PHASE EXTRACTION ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; HPLC METHOD ; MICROCALORIMETRIC MEASUREMENTS ; HUMAN PHARMACEUTICALS ; MASS-SPECTROMETRY ; ANTIDEPRESSANTS ; QUETIAPINE ; CLOZAPINE ; PRODUCTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345382600007 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1465]  |
| 专题 | 武汉物理与数学研究所_高技术创新与发展中心 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Dept Pharmaceut Anal, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Tonghua,Cai, Peishan,Li, Dan,et al. gamma-MPS-Modified Silica Conical Microcolumn Separation/Preconcentration of Trace Antipsychotic Drugs in Rat Plasma and Environmental Water Samples Prior to Their Determination by LC[J]. CHROMATOGRAPHIA,2014,77(23-24):1623-1632. |
| APA | Yang, Tonghua.,Cai, Peishan.,Li, Dan.,Chen, Jing.,Xiong, Chaomei.,...&Wang, Liying.(2014).gamma-MPS-Modified Silica Conical Microcolumn Separation/Preconcentration of Trace Antipsychotic Drugs in Rat Plasma and Environmental Water Samples Prior to Their Determination by LC.CHROMATOGRAPHIA,77(23-24),1623-1632. |
| MLA | Yang, Tonghua,et al."gamma-MPS-Modified Silica Conical Microcolumn Separation/Preconcentration of Trace Antipsychotic Drugs in Rat Plasma and Environmental Water Samples Prior to Their Determination by LC".CHROMATOGRAPHIA 77.23-24(2014):1623-1632. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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