The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast
文献类型：期刊论文
| 作者 | Li, Yongkai1,2; Yi, Ming3,4; Zou, Xiufen1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2014-07-21 |
| 卷号 | 4 |
| 英文摘要 | To gain insights into the mechanisms of cell fate decision in a noisy environment, the effects of intrinsic and extrinsic noises on cell fate are explored at the single cell level. Specifically, we theoretically define the impulse of Cln1/2 as an indication of cell fates. The strong dependence between the impulse of Cln1/2 and cell fates is exhibited. Based on the simulation results, we illustrate that increasing intrinsic fluctuations causes the parallel shift of the separation ratio of Whi5P but that increasing extrinsic fluctuations leads to the mixture of different cell fates. Our quantitative study also suggests that the strengths of intrinsic and extrinsic noises around an approximate linear model can ensure a high accuracy of cell fate selection. Furthermore, this study demonstrates that the selection of cell fates is an entropy-decreasing process. In addition, we reveal that cell fates are significantly correlated with the range of entropy decreases. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | GENE-EXPRESSION ; SACCHAROMYCES-CEREVISIAE ; DIFFERENTIAL-EQUATIONS ; STOCHASTIC SIMULATION ; BIOLOGICAL NOISE ; CYCLE ; KINASE ; PHOSPHORYLATION ; MECHANISM ; DYNAMICS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339157000007 |
| 公开日期 | 2015-07-14 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/1327]  |
| 专题 | 武汉物理与数学研究所_数学物理与应用研究部 |
| 作者单位 | 1.Wuhan Univ, Sch Math & Stat, Wuhan 430072, Peoples R China 2.Wuhan Univ, Sch Comp, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Beijing, Peoples R China 4.Chinese Acad Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yongkai,Yi, Ming,Zou, Xiufen. The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast[J]. SCIENTIFIC REPORTS,2014,4. |
| APA | Li, Yongkai,Yi, Ming,&Zou, Xiufen.(2014).The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast.SCIENTIFIC REPORTS,4. |
| MLA | Li, Yongkai,et al."The linear interplay of intrinsic and extrinsic noises ensures a high accuracy of cell fate selection in budding yeast".SCIENTIFIC REPORTS 4(2014). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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