Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies
文献类型：期刊论文
| 作者 | Wang HJ; Liu JH; Zheng X(郑旭); Rong XH; Zheng XW; Peng HY; Li ZH(李战华); Li MJ; Liu, LY |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-06-04 |
| 卷号 | 5页码:10945 |
| 通讯作者邮箱 | lili@imech.ac.cn ; liu@iphy.ac.cn |
| ISSN号 | 2045-2322 |
| 通讯作者 | Silber-Li, ZH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
| 产权排序 | [Wang, Hujun; Li, Mujun] Univ Sci & Technol China, Dept Precis Machinery & Precis Instrumentat, Hefei 230026, Peoples R China; [Wang, Hujun; Rong, Xiaohui; Liu, Liyu] Chinese Acad Sci, Inst Phys, Key Lab Soft Matter Phys, Beijing 100190, Peoples R China; [Liu, Jinghua; Zheng, Xuwei; Peng, Hongyu] Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China; [Zheng, Xu; Silber-Li, Zhanghua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China |
| 中文摘要 | Percutaneous coronary intervention (PCI), especially coronary stent implantation, has been shown to be an effective treatment for coronary artery disease. However, in-stent restenosis is one of the longstanding unsolvable problems following PCI. Although stents implanted inside narrowed vessels recover normal flux of blood flows, they instantaneously change the wall shear stress (WSS) distribution on the vessel surface. Improper stent implantation positions bring high possibilities of restenosis as it enlarges the low WSS regions and subsequently stimulates more epithelial cell outgrowth on vessel walls. To optimize the stent position for lowering the risk of restenosis, we successfully established a digital three-dimensional (3-D) model based on a real clinical coronary artery and analysed the optimal stenting strategies by computational simulation. Via microfabrication and 3-D printing technology, the digital model was also converted into in vitro microfluidic models with 3-D micro channels. Simultaneously, physicians placed real stents inside them; i.e., they performed "virtual surgeries". The hydrodynamic experimental results showed that the microfluidic models highly inosculated the simulations. Therefore, our study not only demonstrated that the half-cross stenting strategy could maximally reduce restenosis risks but also indicated that 3-D printing combined with clinical image reconstruction is a promising method for future angiocardiopathy research. |
| 类目[WOS] | Multidisciplinary Sciences |
| 分类号 | 一类 |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1038/srep10945 |
| 语种 | 英语 |
| WOS记录号 | WOS:000355724100001 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/54961]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wang HJ,Liu JH,Zheng X,et al. Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies[J]. SCIENTIFIC REPORTS,2015,5:10945. |
| APA | Wang HJ.,Liu JH.,郑旭.,Rong XH.,Zheng XW.,...&Liu, LY.(2015).Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies.SCIENTIFIC REPORTS,5,10945. |
| MLA | Wang HJ,et al."Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies".SCIENTIFIC REPORTS 5(2015):10945. |
入库方式： OAI收割
来源：力学研究所
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