Mechanokinetics of receptor-ligand interactions in cell adhesion
文献类型：期刊论文
| 作者 | Li N(李宁) ; Lv SQ(吕守琴); Zhang Y(章燕); Long M(龙勉)
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| 刊名 | Acta Mechanica Sinica
 |
| 出版日期 | 2015-04 |
| 卷号 | 31期号:2页码:248-258 |
| 通讯作者邮箱 | mlong@imech.ac.cn |
| 关键词 | Receptor-ligand interactions Selectins beta(2) integrins 2D binding kinetics |
| ISSN号 | 0567-7718 |
| 产权排序 | [Li, Ning; Lu, Shouqin; Zhang, Yan; Long, Mian] Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China; [Li, Ning; Lu, Shouqin; Zhang, Yan; Long, Mian] Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China |
| 通讯作者 | Long, M (reprint author), Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China. |
| 中文摘要 | Receptor-ligand interactions in blood flow are crucial to initiate such biological processes as inflammatory cascade, platelet thrombosis, as well as tumor metastasis. To mediate cell adhesion, the interacting receptors and ligands must be anchored onto two apposing surfaces of two cells or a cell and a substratum, i.e., two-dimensional (2D) binding, which is different from the binding of a soluble ligand in fluid phase to a receptor, i.e., three-dimensional (3D) binding. While numerous works have been focused on 3D kinetics of receptor-ligand interactions in the immune system, 2D kinetics and its regulations have been less understood, since no theoretical framework or experimental assays were established until 1993. Not only does the molecular structure dominate 2D binding kinetics, but the shear force in blood flow also regulates cell adhesion mediated by interacting receptors and ligands. Here, we provide an overview of current progress in 2D binding and regulations, mainly from our group. Relevant issues of theoretical frameworks, experimental measurements, kinetic rates and binding affinities, and force regulations are discussed. A neutrophil undergoes capture and rolling (or tethering) on the endothelium through selectin-PSGL-1 bonds, followed by slow rolling and firm adhesion through the -integrins LFA-1 and Mac-1 as well as intraluminal crawling and transmigration through the endothelium to the inflamed tissue. |
| 分类号 | 二类 |
| 类目[WOS] | Engineering, Mechanical ; Mechanics |
| 研究领域[WOS] | Engineering ; Mechanics |
| 收录类别 | SCI ; EI ; CSCD |
| 原文出处 | http://dx.doi.org/10.1007/s10409-015-0407-8 |
| 语种 | 英语 |
| WOS记录号 | WOS:000355315900011 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/54973]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 推荐引用方式 GB/T 7714 | Li N,Lv SQ,Zhang Y,et al. Mechanokinetics of receptor-ligand interactions in cell adhesion[J]. Acta Mechanica Sinica,2015,31(2):248-258. |
| APA | Li N,Lv SQ,Zhang Y,&Long M.(2015).Mechanokinetics of receptor-ligand interactions in cell adhesion.Acta Mechanica Sinica,31(2),248-258. |
| MLA | Li N,et al."Mechanokinetics of receptor-ligand interactions in cell adhesion".Acta Mechanica Sinica 31.2(2015):248-258. |
入库方式： OAI收割
来源：力学研究所
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