Preparation of amphiphilic oligomers of Gd(III) complexes and their liver-selective MRI property
文献类型：期刊论文
| 作者 | Bai, ZW; Yu, KC; Zhuo, RX |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2004-08-01 |
| 卷号 | 25期号:8页码:1582-1584 |
| 关键词 | amphiphilicity oligomeric terpolymer ligand Gd(III) complex liver-selective MR imaging |
| 英文摘要 | Diethylenetriaminepentaacetic dianhydride was co-polymerized with dodecyl ester and benzyl ester of lysine, and octodecyl ester and benzyl ester of lysine respectively to give two terpolymers. These two terpolymer ligands were reacted with GdCl3 to afford amphiphilic oligomers of Gd (III) complexes. These new ligands and Gd (III) complexes were characterized by IR, H-1 NMR and elemental analysis. The oligomeric complexes show a higher relaxivity as compared to that of Gd(DTPA) which is widely used in clinic diagnoses. The Gd (III) complex derived from, octodecyl ester demonstrated liver-selective enhancement for MR imaging of Wistar rat. The ratios of signal to noise (SIN) in the proton intensity imaging were enhanced, respectively, by 15%, 27%, and 36% at the time of 5, 30 and 45 min after injection of this complex. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CONTRAST AGENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223524600052 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4373]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Inst Chem Technol, Dept Chem Engn & Pharmaceut, Wuhan 430073, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, ZW,Yu, KC,Zhuo, RX. Preparation of amphiphilic oligomers of Gd(III) complexes and their liver-selective MRI property[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2004,25(8):1582-1584. |
| APA | Bai, ZW,Yu, KC,&Zhuo, RX.(2004).Preparation of amphiphilic oligomers of Gd(III) complexes and their liver-selective MRI property.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,25(8),1582-1584. |
| MLA | Bai, ZW,et al."Preparation of amphiphilic oligomers of Gd(III) complexes and their liver-selective MRI property".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 25.8(2004):1582-1584. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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