Evaluation of dendritic gadolinium complexes as MRI contrast agents
文献类型：期刊论文
| 作者 | Yan, GP; Bottle, SE; Zhuo, RX; Wei, L; Liu, ML; Li, LY |
| 刊名 | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
 |
| 出版日期 | 2004-11-01 |
| 卷号 | 19期号:6页码:453-465 |
| 关键词 | magnetic resonance imaging (MRI) gadolinium complex dendrimer relaxivity pyridoxamine |
| 英文摘要 | A series of dendritic gadolinium complexes based on dendrimers with 1,4,7,10-tetraazacyclododecane as the core were synthesized. Both diethylenetriaminepentaacetic acid and pyridoxamine were incorporated to the amine groups on the surface to give the dendritic ligands. These dendritic ligands were then reacted with gadolinium chloride to yield the corresponding dendritic gadolinium complexes. The dendritic ligands and their gadolinium complexes were characterized by (HNMR)-H-1, IR, UV and elemental analysis. Relaxivity studies showed that the dendritic gadolinium complexes have higher relaxation effectiveness than that of the clinically used small molecular gadolinium complexes. Magnetic resonance imaging of the liver in rats indicated that the dendritic gadolinium complex containing pyridoxamine enhances the image contrast of the liver, provides prolonged intravascular duration and produces highly contrasted visualization of blood vessels in the liver. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Materials Science, Biomaterials ; Polymer Science |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science |
| 关键词[WOS] | MAGNETIC-RESONANCE ; DENDRIMERS ; MACROMOLECULES ; DYNAMICS ; CHELATE ; TUMORS ; CELLS ; LIVER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225552900002 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4383]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Queensland Univ Technol, Sch Phys & Chem Sci, Brisbane, Qld 4001, Australia 2.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, GP,Bottle, SE,Zhuo, RX,et al. Evaluation of dendritic gadolinium complexes as MRI contrast agents[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2004,19(6):453-465. |
| APA | Yan, GP,Bottle, SE,Zhuo, RX,Wei, L,Liu, ML,&Li, LY.(2004).Evaluation of dendritic gadolinium complexes as MRI contrast agents.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,19(6),453-465. |
| MLA | Yan, GP,et al."Evaluation of dendritic gadolinium complexes as MRI contrast agents".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 19.6(2004):453-465. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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