Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent
文献类型：期刊论文
| 作者 | Sun, GY; Feng, JH; Wu, HF; Pei, FK; Fang, K; Lei, H |
| 刊名 | JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
 |
| 出版日期 | 2004-10-01 |
| 卷号 | 281期号:2-3页码:405-409 |
| 关键词 | gadolinium heteropoly complex magnetic resonance imaging (MRI) contrast agent relaxivity |
| 英文摘要 | Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] has been evaluated by in vitro and in vivo experiments as a potential contrast agent for magnetic resonance imaging (MRI). The thermal analysis and conductivity study indicate that this complex has good thermal stability and wide pH stability range. The T-1 relaxivity is 7.59 mM(-1) s(-1) in aqueous solution and 7.97 mM(-1) s(-1) in 0.725 mmol l(-1) bovine serum albumin (BSA) solution at 25degreesC and 9.39 T, respectively. MR imaging of three male Sprague-Dawley rats showed remarkable enhancement in rat liver after intravenous injection, which persisted longer than with Gd-DTPA. The signal intensity increased by 57.1 +/- 16.9% during the whole imaging period at 0.082 mmol kg(-1) dose. Our preliminary in vitro and in vivo studies indicate that K-17[Gd(P2W17O61)(2)] is a potential liver-specific MRI contrast agent. (C) 2004 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology ; Physical Sciences |
| 类目[WOS] | Materials Science, Multidisciplinary ; Physics, Condensed Matter |
| 研究领域[WOS] | Materials Science ; Physics |
| 关键词[WOS] | HUMAN SERUM-ALBUMIN ; RELAXATION ; CHELATE ; GDDTPA ; DTPA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224236200037 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4416]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, New Drug Res Labs, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, GY,Feng, JH,Wu, HF,et al. Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent[J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,2004,281(2-3):405-409. |
| APA | Sun, GY,Feng, JH,Wu, HF,Pei, FK,Fang, K,&Lei, H.(2004).Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent.JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,281(2-3),405-409. |
| MLA | Sun, GY,et al."Gadolinium heteropoly complex K-17[Gd(P2W17O61)(2)] as a potential MRI contrast agent".JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 281.2-3(2004):405-409. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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