Synthesis of nonionic oligomeric manganese(II) complexes and investigation of their toxicity and T-1-relaxation enhancement
文献类型：期刊论文
| 作者 | Yu, KC; Li, YX; Zhou, JL; Ding, SW; Ye, CH |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2005-09-01 |
| 卷号 | 21期号:5页码:512-516 |
| 关键词 | magnetic resonance imaging(MRI) oligomeric contrast agent nonionic Mn( II ) complex relaxivity acute toxicity relaxation enhancement |
| 英文摘要 | Six nonionic oligomeric I manganese It) complexes with oligomeric phosphate-polyglycol-EDTA ester ligands were synthesized and characterized. The longitudinal, relaxivities of these complexes were measured. One of these complexes, which showed the highest relaxivity, was chosen to be used in the acute toxicity test and the T-1-weighted imaging experiment. It has been found that compared to Gd-DTPA, this nonionic oligomeric Mn(II) complex exhibits no acute toxicity, generates highly enhanced MRI-signals and increases the intention time in the rat liver tissue. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | GADOLINIUM COMPLEXES ; CONTRAST AGENTS ; LIVER-LESIONS ; MN-DPDP |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000232473700002 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4468]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan 4.Natl Sun Yat Sen Univ, Ctrt Nanosci & Nanotechnol, Kaohsiung 80424, Taiwan |
| 推荐引用方式 GB/T 7714 | Yu, KC,Li, YX,Zhou, JL,et al. Synthesis of nonionic oligomeric manganese(II) complexes and investigation of their toxicity and T-1-relaxation enhancement[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2005,21(5):512-516. |
| APA | Yu, KC,Li, YX,Zhou, JL,Ding, SW,&Ye, CH.(2005).Synthesis of nonionic oligomeric manganese(II) complexes and investigation of their toxicity and T-1-relaxation enhancement.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,21(5),512-516. |
| MLA | Yu, KC,et al."Synthesis of nonionic oligomeric manganese(II) complexes and investigation of their toxicity and T-1-relaxation enhancement".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 21.5(2005):512-516. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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