Neurochemical changes in brain induced by chronic morphine treatment: NMR studies in thalamus and somatosensory cortex of rats
文献类型：期刊论文
| 作者 | Xiang, Yun; Gao, Hongchang; Zhu, Hang; Sun, Ninglei; Ma, Yuanye; Lei, Hao |
| 刊名 | NEUROCHEMICAL RESEARCH
 |
| 出版日期 | 2006-10-01 |
| 卷号 | 31期号:10页码:1255-1261 |
| 关键词 | morphine withdrawal H-1 magnetic resonance spectroscopy neurochemicals thalamus somatosensory cortex |
| 英文摘要 | To investigate the effects of chronic morphine treatment and its cessation on thalamus and the somatosensory cortex, an ex vivo high resolution (500 MHz) H-1 nuclear magnetic resonance spectroscopy (NMRS), in the present study, was applied to detect multiple alterations of neurochemicals and/or neurometabolites in the rats. Ten days of chronic morphine administration was observed to markedly increase the total amount of lactate (Lac), myo-inositol (my-Ins) (each P < 0.01) and aspartate (Asp) (P < 0.05), and significantly decrease that of glutamate (Glu) and glutamine (Gln) in the rats thalamus (each P < 0.05). In the somatosensory cortex, chronic morphine was shown to increase the level of Lac and my-Ins, and decrease that of Glu (each P < 0.05). Interestingly, the ratio of Glu/GABA was found to decrease in these two brain areas after chronic morphine treatment, and among the detectable neurochemicals in those two cerebral areas, only taurine (Tau) showed to result in a significant increment in thalamus during the process of morphine discontinuation (P < 0.05). Moreover, the alterations of multiple neurochemicals due to chronic morphine exhibited a tendency of recovery to the normal level over the course of morphine withdrawal. The results suggested that, in thalamus and the somatosensory cortex, chronic morphine administration and its cessation could induce multiple neurochemical changes, which may involve in the brain energy metabolism, activity and transition of neurotransmitters. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | DELTA-OPIOID RECEPTORS ; CENTRAL-NERVOUS-SYSTEM ; CEREBRAL-CORTEX ; AUTORADIOGRAPHIC LOCALIZATION ; OPIATE RECEPTORS ; WITHDRAWAL ; GLUTAMATE ; MECHANISMS ; TOLERANCE ; SPECTROSCOPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000241792900011 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4575]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Sect Cognit Brain Res, Kunming 650223, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Jianghan Univ, Sch Med & Life Sci, Wuhan 430056, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Yun,Gao, Hongchang,Zhu, Hang,et al. Neurochemical changes in brain induced by chronic morphine treatment: NMR studies in thalamus and somatosensory cortex of rats[J]. NEUROCHEMICAL RESEARCH,2006,31(10):1255-1261. |
| APA | Xiang, Yun,Gao, Hongchang,Zhu, Hang,Sun, Ninglei,Ma, Yuanye,&Lei, Hao.(2006).Neurochemical changes in brain induced by chronic morphine treatment: NMR studies in thalamus and somatosensory cortex of rats.NEUROCHEMICAL RESEARCH,31(10),1255-1261. |
| MLA | Xiang, Yun,et al."Neurochemical changes in brain induced by chronic morphine treatment: NMR studies in thalamus and somatosensory cortex of rats".NEUROCHEMICAL RESEARCH 31.10(2006):1255-1261. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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