Experimental metabonomic model of dietary variation and stress interactions
文献类型：期刊论文
| 作者 | Wang, Yulan; Holmes, Elaine; Tang, Huiru; Lindon, John C.; Sprenger, Norbert; Turini, Marco E.; Bergonzelli, Gabriela; Fay, Laurent B.; Kochhar, Sunil; Nicholson, Jeremy K. |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2006-07-07 |
| 卷号 | 5期号:7页码:1535-1542 |
| 关键词 | metabonomics stress blood plasma lipoprotein metabolites long chain polyunsaturated fatty acid LC-PUFAs dietary intervention multivariate data analysis H-1 NMR spectroscopy O-acetyl glycoprotein |
| 英文摘要 | Stress in the form of moderate periods of maternal separation of newborn rats has been postulated to cause permanent changes in the central nervous system and diseases in later life. It is also considered that dietary supplementation with long chain polyunsaturated fatty acids (LC-PUFAs) can potentially ameliorate the effects of stress. The metabolic consequences of early life maternal separation stress were investigated in rats (2- 14 days after birth), either alone or in combination with secondary acute water avoidance stress at 3-4 months of age. The effect of a LC-PUFA-enriched dietary intervention in stressed animals was also assessed. Systematic changes in metabolic biochemistry were evaluated using H-1 nuclear magnetic resonance spectroscopy of blood plasma and multivariate pattern recognition techniques. The biochemical response to stress was characterized by decreased levels of total lipoproteins and increased levels of amino acids, glucose, lactate, creatine, and citrate. Secondary acute water avoidance stress also caused elevated levels of O-acetyl glycoproteins in blood plasma. LCPUFAs dietary enrichment did not alter the metabolic response to stress, but did result in a modified lipoprotein profile. This work indicates that the different stressor types resulted in some common systemic metabolic responses that involve changes in energy and muscle metabolism, but that they are not reversible by dietary intervention. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | MAGNETIC-RESONANCE-SPECTROSCOPY ; PROTON NMR-SPECTRA ; MULTIVARIATE STATISTICAL-ANALYSIS ; POLYUNSATURATED FATTY-ACIDS ; PATTERN-RECOGNITION METHODS ; ACUTE-PHASE GLYCOPROTEINS ; HUMAN-BLOOD-PLASMA ; MATERNAL SEPARATION ; HYPORESPONSIVE PERIOD ; H-1-NMR SPECTROSCOPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238838500004 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4576]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ London Imperial Coll Sci Technol & Med, Div Biomed Sci, Fac Nat Sci, London SW7 2AZ, England 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan 430071, Peoples R China 3.Nestec Ltd, Nestle Res Ctr, CH-1000 Lausanne, Switzerland |
| 推荐引用方式 GB/T 7714 | Wang, Yulan,Holmes, Elaine,Tang, Huiru,et al. Experimental metabonomic model of dietary variation and stress interactions[J]. JOURNAL OF PROTEOME RESEARCH,2006,5(7):1535-1542. |
| APA | Wang, Yulan.,Holmes, Elaine.,Tang, Huiru.,Lindon, John C..,Sprenger, Norbert.,...&Nicholson, Jeremy K..(2006).Experimental metabonomic model of dietary variation and stress interactions.JOURNAL OF PROTEOME RESEARCH,5(7),1535-1542. |
| MLA | Wang, Yulan,et al."Experimental metabonomic model of dietary variation and stress interactions".JOURNAL OF PROTEOME RESEARCH 5.7(2006):1535-1542. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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