Study of rare earth encapsulated carbon nanomolecules for biomedical uses
文献类型：期刊论文
| 作者 | Qu, L; Cao, WB; Xing, GM; Zhang, J; Yuan, H; Tang, J; Cheng, Y; Zhang, B; Zhao, YL; Lei, H |
| 刊名 | JOURNAL OF ALLOYS AND COMPOUNDS
 |
| 出版日期 | 2006-02-09 |
| 卷号 | 408页码:400-404 |
| 关键词 | Gd-metallofullerenol Gd@C-82(OH)(22) stability MRI contrast agent in vivo |
| 英文摘要 | Gd@C-82(OH)(40) has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C-82(OH)(n) with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C-82(OH)(22) of a good stability in vivo, Gd@C-82(OH)(22) was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C-82(OH)(22) is lower than that of Gd@C-82(OH)(40), but still higher than the commercial Gd-DTPA MRI contrast agent. (c) 2005 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering |
| 研究领域[WOS] | Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering |
| 关键词[WOS] | METALLOFULLERENES |
| 收录类别 | ISTP ; SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235445300097 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4608]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100039, Peoples R China 2.Chinese Acad Sci, Inst Phys & Math, State Key Lab Nucl Magnet Resonance & Atom & Mol, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qu, L,Cao, WB,Xing, GM,et al. Study of rare earth encapsulated carbon nanomolecules for biomedical uses[J]. JOURNAL OF ALLOYS AND COMPOUNDS,2006,408:400-404. |
| APA | Qu, L.,Cao, WB.,Xing, GM.,Zhang, J.,Yuan, H.,...&Lei, H.(2006).Study of rare earth encapsulated carbon nanomolecules for biomedical uses.JOURNAL OF ALLOYS AND COMPOUNDS,408,400-404. |
| MLA | Qu, L,et al."Study of rare earth encapsulated carbon nanomolecules for biomedical uses".JOURNAL OF ALLOYS AND COMPOUNDS 408(2006):400-404. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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