Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal
文献类型：期刊论文
| 作者 | Sun, N; Li, Y; Tian, S; Lei, Y; Zheng, J; Yang, J; Sui, N; Xu, L; Pei, G; Wilson, FAW |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2006 |
| 卷号 | 138期号:1页码:77-82 |
| 关键词 | conditioned place preference manganese-enhanced MRI gamma-band EEG drug craving |
| 英文摘要 | The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl2 (200 nL, 80 mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100 Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving. (c) 2005 Published by Elsevier Ltd on behalf of IBRO. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | CONDITIONED PLACE PREFERENCE ; MANGANESE-ENHANCED MRI ; MAGNETIC-RESONANCE ; MORPHINE ; ACTIVATION ; DEPENDENCE ; ADDICTION ; SYSTEM ; BRAIN ; INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235947400009 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4647]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Lab Primate Cognit Neurosci, Kunming 650223, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 43007, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Chinese Acad Sci, Grad Sch, Hunan, Peoples R China 5.Nanhua Univ, Med Sch, Hunan 412000, Peoples R China 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Cell Biol, Shanghai 200031, Peoples R China 9.Univ Arizona, Dept Psychol, Tucson, AZ USA 10.Univ Arizona, Dept Neurol, Tucson, AZ USA |
| 推荐引用方式 GB/T 7714 | Sun, N,Li, Y,Tian, S,et al. Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal[J]. NEUROSCIENCE,2006,138(1):77-82. |
| APA | Sun, N.,Li, Y.,Tian, S.,Lei, Y.,Zheng, J.,...&Hu, X.(2006).Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal.NEUROSCIENCE,138(1),77-82. |
| MLA | Sun, N,et al."Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal".NEUROSCIENCE 138.1(2006):77-82. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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