Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo
文献类型：期刊论文
| 作者 | Li, C; Li, YX; Law, GL; Man, K; Wong, WT; Lei, H |
| 刊名 | BIOCONJUGATE CHEMISTRY
 |
| 出版日期 | 2006-05-17 |
| 卷号 | 17期号:3页码:571-574 |
| 英文摘要 | A bis-hydrated Gd3+ complex based on tris acetic acid-1,4,7,10-tetraazacyclododecane (DO3A) that was functionalized with aza-15-crown-5 demonstrated a nearly optimal water-exchanging rate (k(ex) 3.1 x 10(7) s(-1)) and low acute cytotoxicity. Efficient magnetic resonance signal intensity enhancements and prolonged residence lifetime induced by this small molecular complex in vivo were demonstrated even with one-fifth of the standard dosage used in the clinic. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | MRI CONTRAST AGENTS ; HUMAN SERUM-ALBUMIN ; MACROCYCLIC LIGANDS ; PEG-G-POLY(GDDTPA-CO-L-CYSTINE) ; BIODISTRIBUTION ; OPTIMIZATION ; RELAXIVITY ; MODEL ; RATES ; VITRO |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237576000002 |
| 公开日期 | 2015-07-28 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/4649]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China 2.Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Dept Surg, Hong Kong, Hong Kong, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, C,Li, YX,Law, GL,et al. Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo[J]. BIOCONJUGATE CHEMISTRY,2006,17(3):571-574. |
| APA | Li, C,Li, YX,Law, GL,Man, K,Wong, WT,&Lei, H.(2006).Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo.BIOCONJUGATE CHEMISTRY,17(3),571-574. |
| MLA | Li, C,et al."Fast water-exchange Gd3+-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo".BIOCONJUGATE CHEMISTRY 17.3(2006):571-574. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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